May 2023 Issue

A Greasy Player in Alzheimer’s Disease

Our study using transgenic mice and advanced molecular approach has revealed that cholesterol directly links to the origin of Alz-heimer’s disease.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Alzheimer’s Disease, Amyloid Precursor Protein, Cholesterol

Relationship between Childhood Media Use and Participation and Interest in Extracurricular Activities in Adolescence

This study examines how media exposure during childhood might influence the activities adolescents partake in and enjoy.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Adolescence, Childhood, Extracurricular Activities, Media

Purifying Chlamydomonas Reinhardtii Axonemes to Study Microtubule Bundles

Axonemes were purified from Chlamydomonas Reinhardtii alga cells and used to grow multiple microtubule extensions to then be bundled, to study microtubule bundles.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, axonemes, bundle, Chlamydomonas Reinhardtii, crowding agents, Microtubules

Detection of cyberbullying comments in tweets

XGBoost classifier can be used for cyberbullying detection on social media platforms like Twitter.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Cyberbullying, Machine learning, NLP, Vader Sentiment, XGBoost

Strong signatures of toponium via \(t\bar{t}\) decay in ATLAS

Dileptonically decaying top quarks from simulated toponium events are analysed and distributions of the sum of the transverse momenta are computed.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Dileptonic Decay of Top Quarks, Distribution of Transverse Momenta, Top Quarks, Toponium

Biomedical Devices, Remote Health Monitoring, and Their Impact

Biomedical devices can be used in remote healthcare, which can improve health experiences for various populations.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Biomedical devices, personalized medicine, remote health care, Telehealth

Review: Outstanding hazards of radionuclides from the West Lake Landfill

The lasting effects of radionuclides detected at residences and the hazards they contain.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Radioactive waste, Radionuclides, West Lake Landfill

Pregnancy and COVID-19: The impact on prenatal care and maternal outcomes

Evaluation of five levels of prenatal care utilization and maternal outcomes to compare differences in probability from the pre-COVID-19 period to pandemic periods.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, COVID-19, Maternal Outcomes, Pregnancy, Prenatal Care

Identifying the Status of Telehealth for Cancer Patients in the Rural Northeastern United States

Surveyed oncologists in the rural northeastern United States allow for the prediction of future improvements for cancer care-related telehealth.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Access, cancer, Rural, Telehealth

Employing Machine Learning Techniques and Frameworks to Aid with Automotive Design

Modifying existing machine learning techniques and architectures to design a new generative model tailored to automotive design.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Automotive Design, Generative Models, Machine learning, Stack-Gan

Automating Human Sleep Staging Analysis from Polsomnographic Recordings with a Discrete Hidden Markov Predictive Model

This research project utilized a Discrete Hidden Markov Model to design an algorithm capable of completing human sleep staging analy-sis without the need for a human technician.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Hidden Markov model, polysomnography., sleep staging analysis

Effects of artificial algal-bacterial symbioses (E. Coli K-12, C. Fruendii, & E. Coli MC4100) on microbial hydrogen production

A look into how various bacteria species affect the rate of H2 production in Chlamydomonas algae as a step forward to a hydrogen economy.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, biochemistry, environmental, hydrogen, microbes, Sustainability

Physiologically Efficacious Recycled Synthetic Polymers for Ro-bust Prosthesis Production in Low-income Countries

Through tensile testing and computational analysis, effective synthetic polymers for robust prostheses production are developed.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Assistive Technology, Biomedical Engineering, Prosthesis Production, Synthetic Polymers

Confirming the Suitability of Unnatural Amino Acids as Labels to Monitor Structural Changes in Amyloid-Beta(40) with Two-Dimensional Infrared Spectroscopy

This study uses azidohomoalanine as an unnatural amino acid label to establish its usability as such when monitoring the pathways between monomer and oligomer of Amyloid-Beta (40).

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Amyloid-Beta, label, oligomer

Evaluating the Affinity of Tumor-Specific and Self-Specific CD8+ T Cells in a Liver Cancer Mouse Model

Tumor-specific and self-specific CD8+ T cells have a difference in their affinity to their antigen.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, cancer, CD8+, Immunology

Study on Optimal SARS-CoV-2 Containment Strategies Using Ex-tended SEIR Model

Mathematical modeling and simulation to study epidemic disease spreading and containment considering vaccine and testing impact.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, COVID, Epidemic Disease Modeling, SARS-CoV-2, Virus Containment

Crossing the blood-brain barrier: recent advances in nanoparticle strategies for drug delivery to the CNS

This paper summarizes the latest advances in the clinical translation of nanoparticle-based systems for blood-brain barrier crossing.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Blood Brain Barrier, clinical trials, drug delivery, Nanoparticles

Evaluating Cell Culture Systems for Engulfment Receptor Function: Jedi-1 in BV2 and HeLa Cells

Jedi-1 is not expressed endogenously by BV2 cells; transfection of HeLa cells with Jedi-1 induces engulfment of apoptotic neural cells.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, HeLa, Jedi-1, microglia, Neuroscience

Investigating the Correlation Between Phytoncide and Gut Bacteria to Maintain Strong Immunity and Brain Health of Astronauts

The metabolites of lung cells exposed to phytoncide are used to treat human immune and brain cells to test for the ability of phytoncide to improve immune and brain health in astronauts aboard spacecraft.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Immunity, Microbiome, Phytoncide, Spacecraft

Survival of Tribolium confusum when co-infected with gregarine parasite at different life stages and Bacillus thuringiensis infection

Flour Beetles were exposed to two immune threats to assess how their fitness would change due to the life stage and dosage of the threat.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Bacillus thuringiensis infection, co-infection, parasitic exposure, Tribolium confusum

A Review and Comparative Analysis of Breast Cancer Segmentation Using U-Net and Its Variants

This study evaluates U-net and its attention-based variants for the breast cancer segmentation using WSI of Data Science Bowl 2018.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, breast cancer, Deep learning, Histopathological images

Tracking Provenance of Glacial Sediments in Ong Valley, Antarctica

Comparing sections of till in Ong Valley to track the past movement of the Argosy glacier.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Antarctica, detrital zircon, Ong Valley

Recalibration and Spatial Recall in an Immersive Virtual Environment

A study of the effects of age and gender of spatial memory in a virtual environment.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Locomotion, Spatial Memory, Virtual reality

Automated diagnosis of 7 retinal diseases with convolutional neural networks in a dataset of 2,234 eye images

Automated diagnosis of retinal disease with convolutional neural networks achieving a validation F1-score accuracy of 96% and 95% on cataracts and pathological myopia respectively.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, convolutional neural networks, healthcare, Machine learning

Ligand Dose Response for Different Affinity Synthetic Receptors on an Engineered Biomaterial Surface

Utilizing the synNotch synthetic receptor platform, we tested two different affinity GFP responsive receptors to understand their activa-tion thresholds for purpose of developing a platform for regenerative engineering.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Biomaterials, Pluripotent Stem Cells, Regenerative Engineering, Synthetic Receptors, Tissue Engineering

Devising a Method for Physically Generating Phase Aberration in Ultrasounds Using Phantoms

Creating artificial tissues to physically generate phase aberration in ultrasounds

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Aberration, Phantom, Phase, Ultrasound

Biological Sex and Socioeconomic Status Influences on Behavioral and Neural Markers of Speech Processing in Preschool Children in Brazil

The distinctive impact of socioeconomic status on auditory processing and limited effect on behavioral testing while biological sex shows no overall variance in either measure.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Biological Sex, Cortical Auditory Event-Related Potential (CAEP), P1-N1-P2 complex, Socioeconomic Status (SES)

Determining the value of a cricket player: Does bowling ability have a greater effect on the rating of a cricket player than batting ability?

Using machine learning to analyze and compare how different variables affect the rating of a cricket player

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, cricket, Machine learning, regression, Sports analytics

A ONE-DIMENSIONAL PROOF OF THE HÖLDER INEQUALITY USING THE HEAT EQUATION

This paper displays an alternative approach to proving the Holder Inequality using supersolutions of the Heat Equation for a one-dimensional case.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Heat Equation, Hölder, Inequality

Defining Evaluation Metrics for Medical Imaging Datasets

Define metrics to evaluate medical imaging datasets to improve the accuracy and reliability of model results.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Computer Vision, Dataset Reliability, Medical Imaging Datasets

Defining the Immunogenomics of Allopurinol-Induced SJS/TEN

This study aims to validate the involvement of a known HLA risk allele associated with ALP-SJS/TEN as well as to identify other novel HLA alleles or immune factors associated with disease pathogenesis.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Adverse Drug Reaction (ADR), allopurinol (ALP), cytotoxic CD8+ T-cell, HLA Class I alleles, keratinocytes, Severe Cutaneous Adverse Reaction (SCAR), Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (SJS/TEN), T cell Receptor (TCR)