May 2015 Issue
Analyzing the Role of RIF1 in DNA Double-Strand Break Repair
This work uncovers that the function of RIF1 in DNA Double-Strand Break repair is likely mediated through the Single-Strand Annealing form of Homology-Directed Repair
Posted by Greta Clinton-Selin on Friday, May 1st, 2015 in May 2015, Double-strand break repair, Single-Strand Annealing
A Hybrid Photometric and Spectral Algorithm for Efficient Detection of Gravitationally Lensed Quasars
A novel method was developed to identify gravitationally lensed quasars, consisting of a morphological algorithm directed at finding wide-separation lens candidates and a point spread function (PSF)-difference-based algorithm aimed at identifying close-separation lens candidates.
Posted by Greta Clinton-Selin on Friday, May 1st, 2015 in May 2015, dark energy, dark matter, gravitational lensing, Quasars, SDSS
Investigating the Lymphotoxic Activity of an Ancient Fungal Pathogen of Amphibians
This research looked at how Batrachochytrium dendrobatidis, a fungal pathogen that infects amphibians, is able to suppress immune function.
Posted by Greta Clinton-Selin on Friday, May 1st, 2015 in May 2015, Apoptosis, Batrachochytrium dendrobatidis, lymphocytes
Carbon and Oxygen Isotope Analysis to Document Childhood Diet and Local vs. Non-Local Status among African Slave Burials from the Grassmere Plantation, Nashville, Tennessee
Carbon and oxygen isotope analyses of human teeth from a captive slave population from the Grassmere Plantation in Nashville, Tennessee.
Posted by Greta Clinton-Selin on Thursday, April 30th, 2015 in May 2015, carbon and oxygen isotope analysis, diet reconstruction, migration, slavery
Development of a Two-Photon Lithography System
Development of a Two-Photon Lithography System
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, three-dimensional fabrication, Two-photon Lithography
Experimental Validation of an Ion Simulation Model for Traveling Wave Ion Mobility Spectrometry
Experimental validation of theoretical results from a previously proposed traveling wave ion mobility model.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Computer Simulation, Ion Mobility, Mass Spectrometry
Evaluation of Bigby Cannon Limestone’s Contributions to Pedogenesis Using Element Mass Flux Calculations
Bigby Cannon Limestone was analyzed to see if it contributes to soil development in Middle Tennessee.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Bigby Cannon Limestone, chemical weathering, mass flux
Investigation of the Structure-Activity Relationship of a Dopamine Receptor 4 Antagonist to Treat Cocaine Addiction
This study demonstrates the successful synthesis of drug candidates for potential use as PET tracers and in vivo tool compounds to study and potentially treat cocaine addiction.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Addiction, Compound Synthesis, Dopamine, Receptor Antagonist
Cell Shape Changes During Drosophila Germ Band Retraction: To-wards Model Validation by Experimental Comparison
This project seeks to experimentally validate simulated predictions of forces in a Drosophila embryo during germ band retraction.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Biophysics, Drosophila, embryogenesis, germ band retraction, Morphogenesis
The Effect of Trastuzumab, Paclitaxel, and XL147 Treatment on Aerobic Glycolysis in Breast Cancer Cells
This study evaluated the impact of select cancer treatments on the metabolic glucose consumption and lactate production of breast cancer cells.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, breast cancer, glucose, lactate, metabolism
Development of an Enhanced Microfluidic Platform for Three-Dimensional Neuron Cell Culture
Here the development of a novel microfluidic device is described that enhanced media perfusion that can benefit neurons cultured in a three-dimensional matrix, attempting to model the in vivo microenvironment in the brain.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Microfluidics, Neuron, Polydimethylsiloxane (PDMS)
Analyzing Specific Health Hazards in Perfumes by Identifying Ingredients using Gas Chromatography- Mass Spectrometry
The ingredients in perfumes were identified using Gas Chromatography-Mass Spectrometry then analyzed for health hazards based on data provided on publically available Safety Data Sheets as well as standards set by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Fragrance, Gas Chromatography-Mass Spectrometry, Health Hazard, Perfume, Safety Data Sheets
Activation of Silent Biosynthetic Pathways in Cave Microorganisms for Drug Discovery
Cave microorganisms were exposed to a variety of stimuli for the purpose of secondary metabolic pathway activation and potential acceleration of techniques for drug discovery.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, multivariate statistical analysis, Natural product discovery, secondary metabolite
The Development of a Robot-Assisted Joint Attention Training System for Children with Autism
This research aims to help children with autism develop their social skills.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, autism spectrum disorder, Joint Attention, Robotics
Utilization of LEDs in a Communication Protocol for Endoscopic Submarine Capsules
A protocol for communication among a swarm of endoscopic submarine capsules was developed using light emitting diodes and color sensors.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, capsule endoscopy, color sensor, communication, gastric region, light emitting diode
Characterization of Novel Drugs that Target the Hedgehog Signaling Pathway in Tumor Induced Bone Disease
This research presents information about optimized transfection conditions for MDA-MB- 231 cells, as well as cell viability data on known antagonists.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Bone metastases, Gli2, Hedgehog Signaling Pathway
Investigating the Function of CTGF in β-Cell Mass and Glucose Tolerance During Pregnancy
CTGF is necessary for glucose tolerance during pregnancy, but overall β-cell mass is unchanged at the measured time-point.
Posted by Greta Clinton-Selin on Monday, April 27th, 2015 in May 2015, Gestational diabetes, pancreas, β-cell