May 2026 Issue
Target-Dependent Performance of Molecular Similarity Metrics in Drug Discovery
This study systematically evaluates the molecular similarity principle across eight protein targets and shows that its predictive power varies by protein family.
Posted by buchanle on Friday, June 5th, 2026 in May 2026, activity cliffs, fingerprints, molecular similarity, structure-activity relationships, virtual screening
Qartographer: A Novel Approach to Quantum Chip Design
In this work we present Qartographer, an open-source Python framework for optimizing ancillary control layouts in quantum processors.
Posted by buchanle on Friday, June 5th, 2026 in May 2026, Framework, optimization, Quantum Computing, Quantum Processors, SciPy, Software, Superconducting Qubits
Cellular Deepfake Engine: A Dual-GAN Framework Redefining Data Generation for Biomedical Imaging AI
This study presents the Cellular Deepfake Engine, a novel generative AI framework designed to produce high-fidelity, biologically plausible microscopy images across three domains: blood cells, nuclei, and cancerous cells.
Posted by buchanle on Wednesday, June 3rd, 2026 in May 2026, Biomedical images, Blood cell, Deep learning, Generative Adversarial Network, Nuclei
In Silico Screening of BiTE Molecule Targeting CD22 and T-Cell Receptor Complex for Acute Lymphoblastic Leukemia
This research presents a fully in silico pipeline for engineering a Bispecific T-Cell Engager by identifying and validating scFv antibodies that target CD22 and the T-cell receptor for acute lymphoblastic leukemia therapy.
Posted by buchanle on Wednesday, June 3rd, 2026 in May 2026, Acute Lymphoblastic Leukemia, Bispecific T-Cell Engager, Cancer Cell Hypoxia, CD22 Receptor, T-Cell Receptor
AI Exploration of Non-Linearities in Dark Matter and Supercluster Detection with SRG/eROSITA
Supervised and unsupervised machine learning models are used to find patterns in galaxy cluster and supercluster features.
Posted by buchanle on Wednesday, June 3rd, 2026 in May 2026, dark matter, Galaxy cluster, Machine learning, supercluster
Optimized Control of HVAC systems using Artificial Intelligence
This study aims to develop a Neural Network (NN)-based system that regulates room temperature by generating command signals for the valve and bypass damper in a traditional HVAC setup, given suboptimal past control data.
Posted by buchanle on Wednesday, June 3rd, 2026 in May 2026, Artificial Intelligence, HVAC Systems, Machine learning, Systems and Control
Self-Designing Cells: Evolutionary Algorithms Driving Intelligent Virtual Microbial Systems
Using evolutionary algorithms, this work models how virtual genomes self-optimize traits over time, offering insights into adaptation, complexity, and cellular decision-making.
Posted by buchanle on Wednesday, June 3rd, 2026 in May 2026, Evolutionary, Self-designing, Self-optimisation, Virtual-cells
Student Challenges in Finding Extracurricular Activities: Insights From Testing an AI-Based Discovery System
This study investigates how an AI-enabled agent can address student barriers and enhance participation in high school extracurricular programs.
Posted by buchanle on Tuesday, June 2nd, 2026 in May 2026, AI in the loop educational technology, extracurricular engagement, student motivation, student–AI interaction
Exoplanet Anomaly Tagging Using Clustered Folded TESS Light Curves
This paper provides a novel, unsupervised machine learning pipeline for exoplanet anomaly classification.
Posted by buchanle on Tuesday, June 2nd, 2026 in May 2026, Anomaly Detection, Exoplanet, TESS, Unsupervised
Design and Implementation of High Voltage Pulse Generator in Energizing Magnetized Coils
Arduino Module controlled electronic circuits for generating high voltage pulse by utilizing charging/discharging capacitor and relay bank in energizing four pairs of inductive coils.
Posted by buchanle on Tuesday, June 2nd, 2026 in May 2026, Arduino, Charging/Discharging Capacitor, High Voltage Pulse, Magnetized Coil, Relay
Molecular and Computational Characterization of GLP-1 Receptor–Agonist Binding Mechanisms for Rational Therapeutic Design
This research paper presents a computational pipeline that identifies key GLP-1 Receptor binding determinants and proposes improved liraglutide variants for next-generation weight-management therapies.
Posted by buchanle on Tuesday, June 2nd, 2026 in May 2026, AlphaFold, GLP-1 Receptor, Liraglutide, Weight Management
The Shifting Drivers of Residential Energy Tax Credit Usage: An Ensemble Machine Learning Approach
This longitudinal machine learning analysis reveals that drivers of residential energy tax credit adoption have shifted over time, making educational attainment a key driver and revealing structural barriers that exclude less-educated households from utilizing these tax incentives.
Posted by buchanle on Tuesday, June 2nd, 2026 in May 2026, educational attainment, incentives, random forest regressor, residential energy tax credit, temporal analysis
AI-Driven Molecular Design and Docking of Ferroptosis Inhibitors for Parkinson’s Disease
This study combines AI-driven molecular design with computational docking validation to identify novel ferroptosis inhibitors for Parkinson's disease treatment.
Posted by buchanle on Monday, June 1st, 2026 in May 2026, Drug Discovery, Ferroptosis, Machine learning, Molecular Docking, Parkinson’s disease
GITR-Targeted Small Molecules for Cancer Immunotherapy
A computational investigation identifying and evaluating potential small-molecule binding sites on the GITR protein to inform immunotherapy strategies.
Posted by buchanle on Wednesday, May 20th, 2026 in May 2026, cancer, Drug Discovery, GITR, immune checkpoints, Immunotherapy
Brainwaves and Beats: A Study on the Effects of Music on Cognitive Processes
By examining listening patterns and productivity, this study reveals that calm and structured music can support mental focus in students.
Posted by buchanle on Tuesday, May 19th, 2026 in May 2026, Academic Performance, Cognitive Enhancement, Concentration, Music Cognition, Neuropsychology, Student Productivity, Study Habits, Survey Research
Spatio-Temporal Change Point Characterization in Tropical Forests using a Hybrid Pipeline
A hybrid pipeline including a modified BFAST, convolutional neural network embeddings and a XGBoost achieving a ~97% accuracy on a synthet-ic tropical-forest time series and classify into 5 major classes.
Posted by buchanle on Tuesday, May 19th, 2026 in May 2026, BFAST, convolutional neural network, deforestation detection, synthetic data, tropical forests
Controllable AI-Driven Chord Generation Using Transformer Language Models
A system that analyzes user MIDI files and generates musically coherent continuations using AI.
Posted by buchanle on Tuesday, May 19th, 2026 in May 2026, Creative AI, Machine learning, MIDI Analysis, Music Generation, Transformer Model
Quantifying Patient Narratives to Strengthen Longitudinal Assessment in Chronic Pain
This study presents a computational framework that integrates patient narratives with symptom scales using aspect-based sentiment analysis to generate an interpretable longitudinal wellness index for clinical assessment.
Posted by buchanle on Tuesday, May 19th, 2026 in May 2026, aspect-based sentiment analysis, chronic pain assessment, clinical natural language processing, narrative medicine, wellness index
Caenorhabditis elegans Under the Influence: Testing the Ef-fects of Caffeine and Ethanol on C. elegans Reproduction
Timed exposures to caffeine and ethanol in Caenorhabditis elegans reveal that both reduce reproductive success; chronic caffeine exposure nearly eliminated egg production and viable progeny, while brief peri-ovulatory ethanol exposure increased egg production but sharply reduced embryo viability.
Posted by buchanle on Monday, May 18th, 2026 in May 2026, C. elegans, endocrinology, infertility, reproduction
Applications for a 3D Printed, Handheld, Low-Cost Centrifuge in Separating Pathogenic Bacteria from Biofluids
This study describes the design and testing of a 3D-printed centrifuge for the preparation of saliva samples for disease detection.
Posted by buchanle on Monday, May 18th, 2026 in May 2026, 3D Printing, Centrifugation, Diagnostics
Evaluating the Emotional Salience of Environmental Images Using the Attentional Blink Paradigm
This study assessed the degree of emotional salience elicited by negatively associated environmental images (e.g., pollution) in the Attentional Blink paradigm.
Posted by buchanle on Monday, May 18th, 2026 in May 2026, attentional blink, emotion, environment, imagery, rapid serial visual presentation
Crowdsourced Ligand Design for Selective Inhibition of the KNa1.2 (Slick) Potassium Channel implicated in Developmental Epileptic Encephalopathies
A hybrid strategy of small molecule drug design that combined evolutionary and crowd sourced designs yielded novel synthetically accessible candidate inhibitors of the Kna1.2 channel implicated in developmental epileptic encephalopathies.
Posted by buchanle on Monday, May 18th, 2026 in May 2026, Foldit, KCNT2, KNa1.2, Ligand, REvoLd
Smart Compression Sleeve for Tracking and Recovery Monitoring in Knee Rehabilitation
This study validates a low-cost, sensor-based "Smart Compression Sleeve" that successfully quantifies significant deficits in knee flexion (-27.3%) and postural stability (+38.9%) in patients with injuries, proving its value as an objective tool for data-driven rehabilitation.
Posted by buchanle on Monday, May 18th, 2026 in May 2026, IMU, Knee Rehabilitation, Motion Tracking, Wearable Sensors
Creating a Replicable Methodology for Categorizing Spatial Editing Techniques
This study is a preliminary step to understanding how space is represented in movies - an investigation of spatial reference frames, spatial cues, and conflict between frames and cues that could affect a movie watcher’s perception of space.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Conflict, Lateralization, Shot-Reverse-Shots, Spatial Cues, Spatial Reference Frames
Exploring the Use of Gravel Occurrence Data as an Indicator of Large-Scale Fluvial Events in the Bengal Basin
Analysis of gravel occurrence data revealed a sedimentary series in Western Bangladesh that contained evidence of a large-scale fluvial event in the Early Holocene.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Bengal Basin, Chota Nagpur, Flooding, Gravel, Sedimentology
The Influence of Tutor Engagement, Attention, and Positive Emotions on Student Achievement
This study examines the impact that tutor engagement, attention, and emotions have on student reading growth throughout a 6-week tutoring period.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Attention, emotion, Engagement, Reading comprehension, Tutoring
Advancement of On-Chip Mixing Capabilities for RAPID, a Microfluidic Radiotracer Synthesis Platform
Producing a microfluidic mixing channel for radiotracer synthesis on a lab on chip device.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, microfluidic, Radiotracer, RAPID
Comprehensive Analysis of Variant Effects, Mutation Spectrum, and Functional Enrichment in Familial Hypercholesterolemia- Associated Mutations
This study conducts a large-scale genomic and bioinformatic analysis of familial hypercholesterolemia-associated mutations, revealing variant con-sequences, functional enrichment patterns, and mutation spectrum trends that inform precision gene therapy development.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, familial hypercholesterolemia, gene ontology, genetic variants, LDLR, mutation spectrum
Utilizing Topology Optimization and Additive Manufacturing to Increase Accessibility of Highly Capable UAVs
This project shows how Topology Optimization and 3D Printing can reduce drone weight without sacrificing strength, opening the door to more capable and accessible drones.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Additive Manufacturing, Drone, Topology Optimization
A Token-Level Framework for Quantifying ChatGPT’s Environmental Impacts and a Browser-Based Intervention for Reducing Prompt Resource Use
This study models the water and energy consumption of large-language model inference at the token level and evaluates a Chrome extension that provides real-time eco-feedback to improve user prompt efficiency.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Artificial Intelligence (AI), Environmental Impact Assessment, Large Language Models (LLMs), Token-Level Analysis
Regulation of the PPARꝩ Pathway using Antagonists and In-verse Agonists across 2D and 3D Models
Utilizing the peroxisome proliferator-activated receptor gamma pathway (PPARꝩ) for immunotherapy in lung cancer models.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Immunotherapy, inhibition, lung cancer, Proliferation
Expression and Purification of a Subtilin spaS RiPP Precursor in E. coli
This project attempts to produce the subtilin precursor SpaS in E. coli to support new antibiotic development.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Antibiotic Resistance, Expression, Protein Purification, RiPPs, Subtilin
Clumping Properties of Cat Litter made from Diatomaceous Earth, Bentonite and Wheat Flour Blends
This work deals with the synthesis of cat litter material using sustainable materials and testing their properties.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Bentonite, Cat Litter, Clay, Clump, Sustainability, Wheat Flour
Study of Low Endotoxin Recovery and Its Reversal Strategies
Low Endotoxin Recovery, a false negative in endotoxin testing, was studied comparatively and for viable solutions.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, endotoxin masking, limulus amebocyte lysate (LAL), Low endotoxin recovery (LER)
A Machine Learning Framework for Predicting Speech Outcomes in Cochlear Implant Recipients Using Genetic Markers
This study develops an AI-based Random Forest framework that integrates genetic variants and demographic data to accurately predict speech outcomes after cochlear implantation, supporting personalized prognosis and rehabilitation strategies.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Cochlear implants, genotype, hearing loss, Machine learning, speech outcomes
Resurrecting the Dead-Cone: EEC Analysis of the Dead-Cone in Simulated proton-proton Collisions
An investigation of the Dead-Cone effect in proton-proton collision simulations using the Energy-Energy Correlator.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Dead-Cone, Energy-Energy Correlator, Particle Physics, Proton, RHIC, simulation
Heavy Metal Concentration Changes in Sediment Along the Cumberland River as it Flows Through Nashville and Seasons Change
A waterway study looking at heavy metal concentrations in the Cumberland River and how those concentrations change when moving through farmland to an urban environment (Nashville).
Posted by buchanle on Friday, May 15th, 2026 in May 2026, Cumberland River, Heavy Metals, Sediment, Waterway Pollution
Disability Attitudes and Policy Perceptions in China and the United States: A Cross-National Survey
The paper examines China–United States attitudes toward disability, finding stronger medical-model views in China, greater United States support for equal employment, and disabled Chinese respondents ranking inclusive education as the most effective awareness strategy.
Posted by buchanle on Friday, May 15th, 2026 in May 2026, disability models, People with disability, policy effectiveness, public opinion, social inclusion
Utilizing Salt Accumulation and Organic Carbon as Proxies for Exposure Age Dating in Beacon Valley, Antarctica
An overview of investigating whether salt deposits and organic carbon traces can reveal the environmental history and surface exposure duration of Beacon Valley.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Antarctica, Exposure-Age Dating, McMurdo Dry Valleys, Polar Sciences
Linking Early Life Adversity to Epigenetic Change: A Meta-Analysis of DNA Methylation as a Molecular Memory of Childhood Trauma.
DNA methylation is an epigenetic mechanism that uncovers methylation patterns associated with adversity type, timing, and participant de-mographics.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Early life adversity, Immune System, meta-analysis, methylation
The Effect of Wetland Restoration on Soil Health
Test of 6 sites, 3 restored and 3 not yet restored, pH, Salinity, and growth effect to determine the effect of restoration on soil health.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Grindelia Stricta, Restoration, Soil Health
Female Zebra Finch (Taeniopygia guttata) Preference Test of Male Courtship Song Complexity
An operant preference test was designed to assess female zebra finch preferences towards male courtship song characteristics.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Bird behavior, evolution, operant task, preference, songbird
The Impact of Synonymous Mutations on the Processing of the Foot-and Mouth Disease Virus Capsid Precursor Protein
This research project aims to study the effects of synonymous mutations on the 3cpro interactions with proteins in the assembly of the FMDV capsid.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Attenuation, Codon Sequence, FMDV, Synonymous Mutations, Viral Replication
An Affordable Dynamic Penetrometer for Soil Resistance and Compaction
The creation of a cost-effective device to measure soil compaction.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Geophone, Penetrometer, Soil Compaction, Soil Resistance
An Evidence-Based Wearable Intervention to Improve Sun-Safety Awareness and Support Overall Cognitive Well-Being
This study investigates how a wearable UV-monitoring intervention can improve sun-protection habits, skin-health awareness, and understanding of vitamin D among adolescents.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Adolescents, barriers to adherence, health behaviors, skin cancer prevention, sunscreen use
Gait-Based Evaluation of Zebrafish Spinal Cord Regeneration
Develop and validate a non-lethal, functional methodology for measuring spinal cord regeneration after injury that matches the accuracy of cellular histology while increasing experimental throughput.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Gait, Motor Function Assays, Spinal Cord Regeneration, Zebrafish
Investigating the Role of NCAM-1 and Profilin-2 in Synaptic Re-modeling During Neural Development in C. elegans
This study examines how proteins, Profilin-2 and NCAM-1, play a role in regulating the synaptic remodeling process in restructuring neurons during neural development in C. elegans, offering insight into intracellular mechanisms that shape functional neural circuits.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, C. elegans, NCAM-1, neural development, Profilin-2, synaptic remodeling
Reference-Point Framing and Future Savings: How Anchoring Bias Influences Saving Intentions among Students
This study carries out an empirical analysis on a randomized experiment carried out on high school students to investigate the role of anchoring bias on decision making and how other mediators (such as financial literacy) can mitigate this effect.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Adolescent Decision Making, Anchoring Bias, Behavioral Economics, Reference Point Framing, Saving Intentions
Bridging the Gap: Testing Auditory Vignettes as a Means to Reduce Polarization in American Politics
Auditory vignettes were found to elicit emotions in a political context, but did not reduce the polarization that plagues American politics.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Anger, Anxiety, Kama Muta, Political Polarization
The Effect of a Y-Splitter on the Scale Up of Microsphere Formation
Exploring the difference in the formation of microspheres between a Y-splitter and a Flow-focusing microfluidic device.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, EV, microfluidic, Microsphere
Using Principal Component Analysis to Investigate Changes in the North American Dipole in Future Simulations
Climate models were used to predict the effects of different levels of climate change on the North American climate patterns.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, climate change, Global Climate Models, North American Dipole
Anionic Phospholipids flip by Neo1 regulates Golgi association of Arf-GEF Gea2
This project investigates how the Golgi flippase Neo1regulates protein trafficking by controlling the localization of the Arf-GEF Gea2 through PI4P lipid flipping.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Neo1, Obesity, Phospholipids, Protein Trafficking, Saccharomyces cerevisiae
Coupling of IL-1β and Collagen II Targeting Antibodies using the SpyMask System
A bispecific protein designed to inhibit IL-1β while targeting type II collagen to localize anti-inflammatory therapy in osteoarthritis.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, bispecific antibodies, collagen II targeting, IL-1β inhibition, inflammation, Osteoarthritis
The Fehu Function ᚠ(d) and Exponential Equality
An exposition and analysis of the Fehu Function, its properties, and its place in the realm of mathematics.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, Equality, Exponentiation, Function, Mathematics
Toward Expansion of Biological Plastic Recycling: In Silico Optimization of a Polyurethane-Degrading Metagenomic Urethanase
An artificial intelligence–driven user-friendly enzyme-engineering workflow accelerated the optimization of a metagenomic polyurethane-degrading urethanase.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, AlphaFold2, biological plastic recycling, ProteinMPNN, Urethanase engineering
Using Fluorescence Resonance Energy-Transfer to Observe DNA Hybridization
Monitoring DNA hybridization with FRET
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, DNA, fluorophore, FRET, Hybridization