Identification and Characterization of Helicobacter pylori Genes Regulating DNA Translocation and TLR9 Activation by the Cancer-Associated cag Type IV Secretion System
Novel Helicobacter pylori genes regulating DNA translocation and TLR9 activation were identified and characterized to investigate the role of DNA translocation in gastric cancer development.
Phospho-protein activation was highest at the edges of organoids grown from glioblastoma cell lines, which may indicate key locations for potential treatment targets.
Characterization of the Downstream Effects of Apical Mistrafficking of Epiregulin and Potential for Transformation in Polarized Epithelial Cells
Loss of epithelial polarity and mistrafficking of Epiregulin may be a driving force for cancer in polarized epithelial cells.