Defining the Immunogenomics of Allopurinol-Induced SJS/TEN

This study aims to validate the involvement of a known HLA risk allele associated with ALP-SJS/TEN as well as to identify other novel HLA alleles or immune factors associated with disease pathogenesis.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Adverse Drug Reaction (ADR), allopurinol (ALP), cytotoxic CD8+ T-cell, HLA Class I alleles, keratinocytes, Severe Cutaneous Adverse Reaction (SCAR), Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (SJS/TEN), T cell Receptor (TCR)

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