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‘Tissue Engineering’

The Development of synNotch-Engineered Pluripotent Stem Cells for Synthetic Morphogenesis

Synthetic Notch (synNotch)-engineered H9 hESCs displayed high receptor expression, adhered and activated on an engineered substratum, and induced early gastrulation differentiation via synNotch-regulated WNT signaling.

Posted by buchanle on Tuesday, April 30th, 2024 in May 2024, , , , , ,

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Ligand Dose Response for Different Affinity Synthetic Receptors on an Engineered Biomaterial Surface

Utilizing the synNotch synthetic receptor platform, we tested two different affinity GFP responsive receptors to understand their activa-tion thresholds for purpose of developing a platform for regenerative engineering.

Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, , , , ,

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