Confirming the Suitability of Unnatural Amino Acids as Labels to Monitor Structural Changes in Amyloid-Beta(40) with Two-Dimensional Infrared Spectroscopy
This study uses azidohomoalanine as an unnatural amino acid label to establish its usability as such when monitoring the pathways between monomer and oligomer of Amyloid-Beta (40).
Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Amyloid-Beta, label, oligomer
Evaluating the Affinity of Tumor-Specific and Self-Specific CD8+ T Cells in a Liver Cancer Mouse Model
Tumor-specific and self-specific CD8+ T cells have a difference in their affinity to their antigen.
Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, cancer, CD8+, Immunology
Survival of Tribolium confusum when co-infected with gregarine parasite at different life stages and Bacillus thuringiensis infection
Flour Beetles were exposed to two immune threats to assess how their fitness would change due to the life stage and dosage of the threat.
Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Bacillus thuringiensis infection, co-infection, parasitic exposure, Tribolium confusum
Tracking Provenance of Glacial Sediments in Ong Valley, Antarctica
Comparing sections of till in Ong Valley to track the past movement of the Argosy glacier.
Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Antarctica, detrital zircon, Ong Valley
An Assessment of Diel Patterns in the East Fork Creek, Franklin, TN
A characterization of the health of the East Fork Creek using diel cycles and stream metabolism analysis.
Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Bayesian analysis, Stream metabolism, Water Quality
The effects of verbal instruction, age, and gender on performance and self-efficacy during cognitive tasks in high school students
This study examines the relationship between verbal instruction and self-efficacy, as well as investigating the role of age and gender as predictors of self-efficacy.
Posted by John Lee on Saturday, May 7th, 2022 in May 2022, cognitive tasks, Self-efficacy, verbal instruction
An Assessment of Water Quality and Macroinvertebrate Evenness as Indicators of Stream Health in Six Duck River Tributaries
Comparison between six streams to determine the effects of water quality on macroinvertebrates.
Posted by John Lee on Saturday, May 7th, 2022 in May 2022, Duck River, Electrical Conductivity, Macroinvertebrates, Water Quality
Integrating Geographic Information Systems (GIS) and Historical Data to Justify the Placement of Forts Henry and Donelson
Through modern mapping technology and historical maps, the location of the Tennessee forts is justified.
Posted by John Lee on Saturday, May 7th, 2022 in May 2022, Civil War, GIS, Maps, Tennessee
Observing the effects of familiarity on puzzle completion time in preschool children
Using puzzles to determine if the familiarity of the teacher impacts how long it takes for preschool students to complete the puzzles.
Posted by John Lee on Saturday, May 7th, 2022 in May 2022, Child psychology, Familiarity, Learning development
Crime and Grocery Store Density using Spatial Statistics in ArcGIS
Crime data was collected, analyzed, mapped, and examined for correlations between grocery store density, median household income, and unemployment rate.
Posted by John Lee on Saturday, May 7th, 2022 in May 2022, Crime, Food Deserts, Geographic Information Systems, Income, Unemployment
Global Patent Landscape of Induced Pluripotent Stem Cells
Review and analysis of worldwide patent literature regarding induced pluripotent stem cells.
Posted by John Lee on Thursday, May 20th, 2021 in May 2021, induced pluripotent stem cells, Intellectual Property, iPSC, Patent Landscape
Adipose Tissue Macrophage Transcriptome Suggests Trained Innate Immunity Formation in Response to Weight Cycling
Single cell sequencing suggests evidence of trained innate immunity in adipose tissue macrophages from weight cycled mice.
Posted by John Lee on Thursday, May 20th, 2021 in May 2021, Adipose tissue macrophages, Obesity, trained innate immunity, weight cycling
The Biological Concepts and Treatment Therapies of Rhabdoid Tumors
This review will explore the biology behind rhabdoid tumors and current/potential future treatment therapies.
Posted by John Lee on Wednesday, May 19th, 2021 in May 2021, AT/RT, MRT, Rhabdoid Tumors
Enabling Far-Infrared Nanophotonics with 2D Materials
The dielectric functions of several 2D materials were extracted in order to determine the infrared optical properties of these materials.
Posted by John Lee on Thursday, December 24th, 2020 in May 2019, 2D materials, dichalcogenides, dielectric function, infrared, nanophotonics
Development of an Educational Platform for Teaching Young Students Complex Networking Topics using the Parallax BadgeWX
A platform was created that allows students to more thoroughly engage in group learning using models that teach complex networking concepts.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, Learning, Modeling, Parallax, Technology
Developing remote procedure calls for NetsBlox to facilitate climate change lessons in K-12 STEM education
Climate change services were implemented into NetsBlox, as linking computer science to outside fields of science is an effective method of teaching programming.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, block-based programming, climate change, Computer science education, K-12 education, STEM education
Development of a Python-based Platform for Teaching Computer Science
This project consists of the creation of a robotics platform built on Python and a curriculum for middle and high school students in order to increase the amount of students interested in computer science.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, Computer Science, education, python, Roboscape, Robotics
The effects of C2STEM on student mastery and motivation in learning marine biology concepts and developing computational thinking skills
A computational thinking-based curriculum is an effective and productive tool for facilitating a transition into an interdisciplinary approach to precollege education.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Computational thinking, K-12 education, learning by modeling, marine biology education, synergistic learning
Imputing Gene Expression in Twelve Ancient Europeans
Analysis of the viability of applying a prediction model to impute the gene expression of ancient humans.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Ancient humans, Imputation, PrediXcan
Integrating ligand- and receptor-based descriptors in deep neural network QSAR
We demonstrated the functionality of a novel drug discovery technique in a proof-of-concept study.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Computer-aided drug discovery, deep neural networks, Machine learning, protein binding-pockets, QSAR modeling
In Vitro Analysis of Synergy between Adjuvants MPLA, CpG, and cGAMP for Treatment of Cancer
Synergistic application of adjuvants was used to analyze interferon and NF-κB immunological responses in mouse macrophages for the treatment of cancer.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Adjuvant, Cancer Immunotherapy, Immunological response, STING pathway
Identification and Characterization of Helicobacter pylori Genes Regulating DNA Translocation and TLR9 Activation by the Cancer-Associated cag Type IV Secretion System
Novel Helicobacter pylori genes regulating DNA translocation and TLR9 activation were identified and characterized to investigate the role of DNA translocation in gastric cancer development.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, cancer, gastric, Helicobacter, pylori, TLR9
SPRR3 Regulates the Cooperative Signaling of Integrins and Growth Factor Receptors to Modulate Cardiac Fibrosis
The SPRR3 protein does not affect individual integrin function in fibroblasts, supporting that SPRR3 influences the cooperative signaling of integrins and growth factor receptors.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, Fibroblast, Growth Factor Receptor, Heart Failure, Integrin, SPRR3 protein
An Analysis of Ice Sheet – Ice Shelf Mechanics through Finite Element Models
A 2D computational model of an idealized ice sheet was created and validated to understand the relations between ice sheet-ice shelf geometry and mechanical stress.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, Finite element model, Fracture, Ice sheet, Mechanical stress
A Multi-User Collaborative Game Created to Improve Cognitive and Physical Aspects and Socialization Skills of Individuals with Dementia
A multi-user collaborative game was created to improve the socialization skills and cognitive aspects of individuals with dementia.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, Dementia, Razer Hydra, Unity
Crime Prediction and Optimal Police Allocation
In this report, we use the transportation problem, a classical optimization problem, to optimize police allocation and survival analysis to predict crime. By doing this, we minimize the overall response time for police officers.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, Crime prediction, optimization, police allocation
Cortical Evoked Potentials Identify Compensatory Effects of Attention on Auditory Processing in Children and Adults
This study examines the effects of noise, attention, and age on neural processing of speech.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, auditory processing, event-related potentials, N1, Speech-in-noise perception
Development of a Machine Learning Algorithm for the Prediction of Enhancer Region Activity
A machine learning algorithm was programmed and optimized to predict the activity of enhancer regions of DNA.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, algorithm, enhancer, genetics, Machine learning, prediction
An Analysis on the Impact of Peer-Mediated Theatre Interventions for Children with Autism on Typically Developing Peers
The analysis of changes in model peers during behavioral interventions designed for children with Autism Spectrum Disorder.
Posted by Greta Clinton-Selin on Monday, June 5th, 2017 in May 2017, Behavioral Intervention, Peer-Study, Salivary Cortisol
Stable Isotope and Dental Microwear Ecology of the Arid Adapted Red Kangaroo (Macropus rufus)
Analysis of the relationship between climate, isotopes, and dental microwear for the red kangaroo.
Posted by Greta Clinton-Selin on Friday, June 2nd, 2017 in May 2017, aridity, climate, diet, microwear, Stable isotopes
Analyzing the Efficacy of Different Gas Chromatography-Mass Spectrometry Methods in Determining Glucose Concentrations
Measuring multiple glucose concentrations using a Gas Chromatography-Mass Spectrometry based technique.
Posted by Greta Clinton-Selin on Thursday, June 1st, 2017 in May 2017, diabetes, Gas-Chromatography-Mass Spectrometry (GC-MS), Glucose Cycling, total ion abundance screening
The Impact of Connective Tissue Growth Factor on Glucose Home-ostasis and Islet Physiology in Virgin and Pregnant Mice
The loss of Connective tissue growth factor (Ctgf) does not affect islet physiology, indicating other existing problems in glucose homeostasis.
Posted by Greta Clinton-Selin on Tuesday, May 30th, 2017 in May 2017, Connective Tissue Growth Factor (Ctgf), diabetes, glucose, Islet, Physiology
Analyzing Phospho-signaling in Human Glioblastoma Cell Lines Using Ex Vivo Culture
Phospho-protein activation was highest at the edges of organoids grown from glioblastoma cell lines, which may indicate key locations for potential treatment targets.
Posted by Greta Clinton-Selin on Thursday, May 25th, 2017 in May 2017, cancer, Epidermal Growth Factor Receptor (EGFR), Glioblastoma, Organoid, phospho-protein activation
Measuring the degradation of robot components caused by gamma radiation.
Individual component radiation testing is an effective way to gather data for the development of modeling software to predict a system's radiation response.
Posted by Greta Clinton-Selin on Friday, June 3rd, 2016 in May 2016, Bayesian Network model, Gamma radiation, Pololu robot
Obesity Contributes to an Accumulation of Ly6chigh Pro-inflammatory Monocytes in the Spleen and White Adipose Tissue
The purpose of this experiment was to see whether or not obesity correlated with an increase in pro-inflammatory monocytes
Posted by Greta Clinton-Selin on Friday, June 3rd, 2016 in May 2016, Immune System, Immunology, Monocytes, Obesity
Assessment of Hedgehog/GLI2 signaling inhibitors within metastatic breast cancers
Hedgehog pathway inhibitors were established as potential remediation treatments for tumor-induced bone disease. Additionally, hypotheses concerning inhibition methods were established for future investigation.
Posted by Greta Clinton-Selin on Friday, June 3rd, 2016 in May 2016, Gli2, Hedgehog Pathway Inhibitor, Metastatic Breast Cancer, PTHrP
The Role of the Non-Canonical NF-kB Pathway in Benign Prostatic Hyperplasia
The Role of the Non-Canonical NF-kB Pathway in Benign Prostatic Hyperplasia
Posted by Printess Berry on Thursday, October 15th, 2015 in May 2014, NF-kB, non-canonical, Prostate benign, prostatic hyperplasia
Tablet Technology to Improve Colonoscopy
Tablet Technology to Improve Colonoscopy
Posted by Printess Berry on Tuesday, October 13th, 2015 in May 2014, collaboration, Endoscopy, wireless integration
The Role of HNF6 on Pancreatic Cancer
The effects of the acinar-specific inactivation of the Hnf6 transcription factor in pancreatic cancer as well as the correlation between PanIN progression to pancreatic cancer and HNF6 expression were studied here. Authors:
Posted by Printess Berry on Tuesday, September 15th, 2015 in May 2011, adenocarcinoma, exocrine, HNF6, Pancreatic, PanIN
A Comparison of Co-Occuring Sexual Versus Gynogenetic Reproductive Strategies in the Sycamore Leaf Beetle, Neochlamisus platani
A comparison between sexual and gynogenetic Neochlamisus platani leaf beetles was conducted through feeding/mating choice tests.
Posted by Printess Berry on Tuesday, September 15th, 2015 in May 2011, ecology, gynogenesis, Neochlamisus, reproduction
Coronavirus Subversion of Host Cell Membranes
This study focused on the novel use of dextrans to assess the capacity for a model Coronavirus to induce macropinocytosis through the course of infection.
Posted by Printess Berry on Tuesday, September 15th, 2015 in May 2011, Coronavirus, dextrans, macropinocytosis
Method for Overcoming Bandwidth Limitations of Standard Fluorescence Microscopy
A procedure for measuring fluorescence from multiple sources in microfluidic devices.
Posted by Printess Berry on Tuesday, September 15th, 2015 in May 2011, CD45, fluorophore, microfluidic, photobleaching, relabeling
MTG16 and Zbtb Family Members Interact to Repress the Wnt Target Matrilysin
Determination of the interaction between MTG16 and Zbtb family members and their ability to repress the Wnt target matrilysin.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, Colon cancer, MTG16, Wnt pathway, Zbtb family members
Rotary Fluidic Feed-through Device for Use in Microfluidics
The fabrication of a novel microfluidic device for use in centrifugal microfluidics.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, Centrifugal microfluidics, Microphysiometry
Regulation of Chemoattractant-mediated G protein Signaling
The use of fluorescence microscopy to observe the localization of signaling molecules.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, cancer, cytokinesis chemotaxis, Dictyostelium discoideum, G protein
An Evaluation of Bid Phosphorylation Status in Myeloid Malignancies
An assay was optimized to query a correlation between Bid protein phosphorylation and the development of acute myelogenous leukemia.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, Bid phosphorylation, Leukemia, Western blot
Electrospun Fiber with Microfluidic Device as a New Template to Study Endothelial Cell Alignment
The development of a microfluidic device to study endothelial cell alignment in the presence of competing stimuli.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, cell alignment, Endothelial cells, microenvironment, Microfluidics
Reconstructing Climate Change and Food Production in the Ancient Peruvian Andes Using Stable Isotope Analysis
Testing the effectiveness of stable isotope analysis in reconstructing climate change and diet in the ancient Peruvian Andes.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, climate change, enamel hydroxyapatite, isotope analysis, Peruvian Andes, stable carbon, Stable oxygen
Human Hemoglobin Polymorphisms Aff ect Recognition by S. aureus Receptor IsdB
Bacterial adenylate cyclase two-hybrid assay shows that hemoglobin variants are differentially bound by S. aureus receptor IsdB
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, hemoglobin, iron, metal-acquisition, polymorphism, Staphylococcus
Low Volume Bacterial Chemostat in Microfl uidic Devices Through the Use of Hexagonal Traps.
Low volume bacterial chemostat: Novel method aimed at rapid diagnosis of bacterial infections.
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, chemostat, E.coli OP50, rotary planar peristaltic micropum, Sepsis, Sepsis chemostat E.coli OP50 microfluidic
Effects of IIIM1 on Rat Astrocytes
Designed to study a peptide’s ability to protect cells exposed to manganese chloride
Posted by Printess Berry on Thursday, August 27th, 2015 in May 2012, IIIM1, Manganese, oxidative stress, Parkinson’s disease, peptide