The Development of synNotch-Engineered Pluripotent Stem Cells for Synthetic Morphogenesis
Synthetic Notch (synNotch)-engineered H9 hESCs displayed high receptor expression, adhered and activated on an engineered substratum, and induced early gastrulation differentiation via synNotch-regulated WNT signaling.
Posted by buchanle on Tuesday, April 30th, 2024 in May 2024, bioactive materials, gastrulation, synthetic biology, Synthetic development, Tissue Engineering, WNT signaling
Ligand Dose Response for Different Affinity Synthetic Receptors on an Engineered Biomaterial Surface
Utilizing the synNotch synthetic receptor platform, we tested two different affinity GFP responsive receptors to understand their activa-tion thresholds for purpose of developing a platform for regenerative engineering.
Posted by John Lee on Tuesday, May 30th, 2023 in May 2023, Biomaterials, Pluripotent Stem Cells, Regenerative Engineering, Synthetic Receptors, Tissue Engineering
Global Patent Landscape of Induced Pluripotent Stem Cells
Review and analysis of worldwide patent literature regarding induced pluripotent stem cells.
Posted by John Lee on Thursday, May 20th, 2021 in May 2021, induced pluripotent stem cells, Intellectual Property, iPSC, Patent Landscape