The Role of Aurora Kinase A (AURKA) in Regulating Translation of Oncogenes in Gastrointestinal Cancers

Aurora kinase A (AURKA) is frequently amplified and overexpressed in gastrointestinal cancers. In this report, we show that AURKA and EIF4E regulate the expression of the same oncogenes, suggesting that AURKA could play a role in regulating EIF4E-cap dependent translation of oncogenes. Inhibition of AURKA could be a plausible therapeutic approach in these cancers.

Posted by Greta Clinton-Selin on Tuesday, May 16th, 2017 in May 2017, Gastrointestinal cancers, inhibition of AURKA, oncogenes, translation

Read more