Coupling of IL-1β and Collagen II Targeting Antibodies using the SpyMask System
A bispecific protein designed to inhibit IL-1β while targeting type II collagen to localize anti-inflammatory therapy in osteoarthritis.
Posted by buchanle on Thursday, May 14th, 2026 in May 2026, bispecific antibodies, collagen II targeting, IL-1β inhibition, inflammation, Osteoarthritis
Optimization of Expression and Purification of an Anti-Inflammatory Binding Motif
This study outlines the development of a protocol for producing codon-optimized Gevokizumab scFv to hinder IL-1β activation, with findings that suggest enhanced protein expression in optimized constructs, which paves the way for potential therapeutic applications in inflammatory diseases.
Posted by buchanle on Wednesday, June 25th, 2025 in May 2025, Gevokizumab, Inflammatory, Osteoarthritis, Protein Expression, scFv