{"id":28,"date":"2017-04-19T16:13:36","date_gmt":"2017-04-19T16:13:36","guid":{"rendered":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/?page_id=28"},"modified":"2019-05-15T15:06:49","modified_gmt":"2019-05-15T15:06:49","slug":"publications","status":"publish","type":"page","link":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

ORCID:<\/strong> 0000-0001-9005-611X<\/a>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 SCOPUS ID:<\/strong>\u00a07102642628<\/a><\/p>\n

2019<\/strong><\/p>\n

(129) Chen, H., Yao, L., Rizzo, C. J., Turesky, R. J.\u00a0Quantitation of Apurinic\/Apyrimidinic Sites in Isolated DNA and in Mammalian Tissue with Reduced Artifact<\/a>, \u00a0Anal. Chem.<\/em>, 2019<\/strong>, 91<\/em>, (accepted<\/em>).\u00a0PMID: 31055913<\/strong><\/a><\/p>\n

2018<\/strong><\/p>\n

(128) Bamberger, S.N., Malik, C.K., Voehler, M.W., Brown, S.K. Pan, K., Johnson Salyard, T.L., Rizzo, C.J., Stone, M.P., Conformational Equilibria of the N<\/em>6<\/sup>-(2-Deoxy-D-erythro<\/em>-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dG) Lesion in DNA<\/a>.\u00a0Chem. Res.\u00a0Toxic.<\/i>\u00a02018<\/strong>, 924-935.\u00a0PMCID:\u00a0<\/a>PMC6352716<\/a><\/strong><\/p>\n

2017<\/strong><\/p>\n

(127) Minko, I.G., Rizzo, C.J., Lloyd, R.S. (2017)\u00a0Mutagenic Potential of Nitrogen Mustard Formamidopyrimidine DNA Adduct<\/a>, J. Biol. Chem.<\/em>\u00a0292, 18790-18799.\u00a0PMCID: PMC5704464<\/strong><\/a><\/p>\n

(126)\u00a0Sha, Y.,\u00a0Minko, I.G., Malik, C.K., Rizzo. C.J., Lloyd, R.S. (2017)\u00a0Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct,<\/a>\u00a0Environ. Mol. Mutagen.\u00a058<\/em>,\u00a0182-189. (feature article).\u00a0PMCID: PMC5476229<\/strong><\/a><\/p>\n

2016<\/strong><\/p>\n

(125) Bose, A., Millsap, A..D., DeLeon A., Rizzo, C.J., Basu, A .K. (2016) Translesion Synthesis of the N2-2′-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase \u03ba and Mutagenic Bypass by DNA Polymerases \u03b7, \u03b6, and Rev1<\/a>, Chem. Res. Toxicol.<\/em> 29<\/em>, 1549-1559. (cover article<\/a>) PMCID: PMC5031085<\/strong><\/a><\/p>\n

(124) Minko, I. G., Jacobs, A. C., Donley, N., Gruppi,F., Harris, T. M., Rizzo,C. J., McCullough, A. K,. Lloyd, R. S. (2016) Catalysts of DNA strand cleavage at apurinic\/apyrimidinic sites<\/a>, Sci. Rep. (Nature), 6<\/em>, 28894; doi: 10.1038\/srep28894. PMCID:\u00a0<\/strong><\/a>PMC4929455<\/a><\/strong><\/p>\n

(123) Thiaville, J. J., Kellner, S. M., Yuan, Y., Hutinet, G., Thiaville, P. C., Jumpathong, W., Mohapatra, S., Brochier-Armanet, C., Letarov, A. V., Hillebrand, R., Malik, C. K., Rizzo, C. J. Dedon, P. C., de Cr\u00e9cy-Lagard, V. (2016) Novel genomic island modifies DNA with 7-deazaguanine derivatives<\/a>, Proc. Natl. Acad. Sci. U.S.A<\/em>., 113<\/em>, E1452\u2013E1459. PMCID: PMC4801273<\/a><\/strong><\/p>\n

2015<\/strong><\/p>\n

(122) Gruppi, F., Hejzai, L., Christov, P. P., Krishnamachari, S., Turesky, R. J., Rizzo, C. J. (2015) Characterization of nitrogen mustard formamidopyrimidine adduct formation of bis-(2-chloroethyl)ethylamine with calf thymus DNA and human mammary cancer cell line<\/a>, Chem. Res. Toxicol. 28<\/em>, 1850-1860. PMCID: PMC4579055<\/strong><\/a><\/p>\n

(121) Bose, A., Pande, P., Jasti, V. P., Millsap, A. D., Hawkins, E. K., Rizzo, C. J., Basu, A. K. (2015) DNA polymerases \u03ba and \u03b6 cooperatively perform mutagenic translesion synthesis of the C8-2\u2019-deoxyguanosine adduct of the dietary mutagen IQ in human cells<\/a>, Nucleic Acids Res.<\/em> 43<\/em>, 8340-8351. PMID: 26220181<\/strong><\/a><\/p>\n

(120) Stavros, K. M., Hawkins, E. K., Rizzo, C. J., Stone, M. P. (2015) Base-displaced intercalated conformation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG DNA adduct positioned at the non-reiterated G1 in the NarI restriction site<\/a>, Chem. Res. Toxicol.<\/em> 28<\/em>, 1455-1468. PMCID: PMC4511292<\/strong><\/a><\/p>\n

(119) Patra, A., Banerjee, S, Johnson-Salyard, T., Malik, C., Christov, P., Rizzo, C. J., Stone, M. P., Egli, M. (2015) Structural basis for error-free bypass of the 5-N<\/em>-methyl-formamidopyrimidine-dG lesion by human DNA polymerase \u03b7<\/strong> and sulfolobus solfataricus<\/em> P2 polymerase IV (Dpo4)<\/a>, J. Am. Chem. Soc.<\/em> 137, 7011-7014. PMCID: PMC45452697<\/a><\/strong><\/p>\n

(118) Zd\u017calik, D., Doma\u0144ska, A., Prorok, P., Kosicki, K., van den Born, E., Falnes, P. \u00d8., Rizzo, C. J., Guengerich, F. P., Tudek, B. (2015) Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins<\/a>, DNA Repair, 30<\/em>, 1-10. PMCID: PMC4451939<\/a><\/strong><\/p>\n

(117) Chang, S.-c., Fedeles, B. I., Wu, J., Delaney, J. C., Li, D., Zhao, L., Christov, P. P., Yau, E., Singh, V., Jost, M., Drennan, C. L., Marnett, L. J., Rizzo, C. J., Levine, S. S., Guengerich, F. P., Essigmann, J. M. (2015) Next-generation sequencing reveals the biological significance of the N<\/em>2,3-ethenoguanine lesion in vivo<\/em><\/a>, Nucleic Acids Res.<\/em> 43<\/em>, 5489-5500. PMCID: PMC44776462<\/a><\/strong><\/p>\n

2014<\/strong><\/p>\n

(116) Singh, V., Fedeles, B. I., Li, D., Delaney, J. C., Kozekov, I. D., Kozekova, A., Marnett, L. J., Rizzo,C. J., Essigmann, J. M. (2014) Mechanism of repair of the acrolein- and malondialdehyde-derived exocyclic guanine adducts by the \u03b1-ketoglutarate\/Fe(II) dioxygenase AlkB<\/a>, Chem. Res. Toxicol.<\/em> 27<\/em>, 1619-1631. PMCID: PMC4164229<\/a><\/strong><\/p>\n

(115) Christov, P. P., Son, K.-J., Rizzo, C. J. (2014) Synthesis and characterization of oligonucleotides containing a nitrogen mustard formamidopyrimidine monoadduct of deoxyguanosine,<\/a> Chem. Res. Toxicol. 27<\/em>, 1610-1618. (cover article<\/a>) PMCID: PMC4164228<\/a><\/strong><\/p>\n

(114) Petrova, K., Millsap, A. D., Stec, D.F., Rizzo, C. J. (2014) Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal<\/a>, Chem. Res. Toxicol. 27<\/em>, 1019\u20131029. PMCID: PMC4060920<\/strong><\/a><\/p>\n

(113) Gruppi, F., Johnson-Salyard, T. L., Rizzo, C. J. (2014) Synthesis of G-N<\/em>2-(CH2)3-N<\/em>2-G Trimethylene DNA interstrand cross-links<\/a>, Curr. Prot. Nucleic Acid Chem.<\/em> 5.14.1\u00ad\u20135.14.15 (supplement 56<\/em>). PMCID: PMC4242527<\/strong><\/a><\/p>\n

(112) Stavros, K. M., Hawkins, E. K., Rizzo, C. J., Stone, M. P. (2013) Base-Displaced Intercalation of the 2-Amino-3-methylimidazo[4,5-f]quinolone N<\/em>2-dG Adduct in the NarI DNA Recognition Sequence<\/a>, Nucleic Acids Res.<\/em> 41, <\/em>3450-63. PMCID: PMC3950664<\/strong><\/a><\/p>\n

2013<\/strong><\/p>\n

(111) Maddukuri, L., Shuck, S., Eoff, R., Zhao, L., Rizzo, C, J., Guengerich, F. P., Marnett, L. J. (2013) Replication, Repair and Translesion Polymerase Bypass of N6-Oxopropenyl-2′-deoxyadenosine<\/a>, Biochemistry<\/em>, 52<\/em>, 8766-8776. PMCID: PMC3925671<\/strong><\/a><\/p>\n

(110) Shell, S. M., Hawkins, E. K., Tsai, M.-S., Rizzo, C. J., Chazin, W. J. (2013) Xeroderma pigmentosum<\/em> complementation group C protein (XPC) serves as a general sensor of damaged DNA<\/a>, DNA Repair<\/em>, 12<\/em>, 947-953 PMCID: PMC3825762<\/strong><\/a><\/p>\n

(109) Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M., Stone, M. P. (2013) Ring-opening of the \u03b3-OH-PdG adduct promotes error-free bypass by the Sulfolobus solfataricus<\/em> DNA polymerase Dpo4<\/a>, Chem. Res. Toxicol.<\/em> 26<\/em>, 1348-1360. PMCID: PMC3775444<\/strong><\/a><\/p>\n

(108) Christov, P. P., Hawkins, E. H., Kett, N. R., Rizzo, C. J. (2013) Simplified synthesis of individual stereoisomers of the 4-hydroxynonenal adducts of deoxyguanosine<\/a>, Tetrahedron Lett.<\/em> 54<\/em>, 4289-4291. PMCID: PMC3735235<\/strong><\/a><\/p>\n

(107) Earley, L., Minko, I. G., Christov, P. P., Rizzo, C. J., Lloyd, R. S. (2013) Mutagenic spectra arising from replication bypass of the 2,6-diamino-4-hydroxy-N5-methyl formamidopyrimidine adduct in primate cells<\/a>, Chem. Res. Toxicol.<\/em> 26<\/em>, 1108-1114. PMCID: PMC3830661<\/a><\/strong><\/p>\n

2012<\/strong><\/p>\n

(106) Zhao, L., Pence, M. G., Christov, P. P., Wawrzak, Z., Choi, J.-Y., Rizzo, C. J., Egli, M., Guengerich, F. P. (2012) Basis of miscoding of the DNA adduct N<\/em>2,3-ethenoguanine by human Y-family DNA polymerases<\/a>. J. Biol. Chem. 287<\/em>, 35516-35526. (cover article<\/a>) PMCID: PMC3471744<\/a><\/strong><\/p>\n

(105) Christov, P. P., Yamanaka, K., Choi, J.-Y., Takata, K.-I., Wood, R. D., Guengerich, F. P., Lloyd, R. S., Rizzo, C. J. (2012) Replication of the 2,6-diamino-4-hydroxy-N<\/em>5-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases<\/a>. Chem. Res.Toxicol.<\/em> 25<\/em>, 1652-61. PMCID: PMC3682502<\/strong><\/a><\/p>\n

(104) Zhao, L., Christov, P. P., Kozekov, I. D., Pence, M. G., Pallan, P. P., Rizzo, C. J., Egli,M., Guengerich, F. P. (2012) Replication of N2,3-ethenoguanine by DNA polymerases<\/a>. Angew. Chem. Int. Ed. Eng.<\/em>, 51<\/em>, 5466-5469. PMCID: PMC3671877<\/strong><\/a><\/p>\n

(103) Banerjee, S., Christov, P. P., Kozekova, A., Rizzo, C. J., Egli, M., Stone, M. P. (2012) Replication Bypass of the trans<\/em>-4-hydroxynonenal-derived (6S,8R,11S) 1,N<\/em>2-deoxyguanosine DNA adducts by the Sulfolobus solfataricus<\/em> DNA polymerase IV<\/a>. Chem. Res. Toxicol., 25<\/em>, 422-435. PMCID: PMC3285121<\/strong><\/a><\/p>\n

2011<\/strong><\/p>\n

(102) Harris, C. M., Stec, D. F., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Harris, T. M., (2011) Deoxyguanosine forms a bis-adduct with E<\/em>,E<\/em>-muconaldehyde, an oxidative metabolite of benzene. Implications for the carcinogenicity of benzene<\/a>. Chem. Res. Toxicol., 24<\/em>, 1994-1956. PMCID: PMC3408037<\/strong><\/a><\/p>\n

(101) Huang, H., Wang, H., Kozekova, A., Rizzo, C. J., Stone, M. P. (2011) Formation of a N<\/em>2-dG:N<\/em>2-dG carbinolamine DNA cross-link by a trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N<\/em>2-dG adduct.<\/a> J. Am. Chem. Soc., 133<\/em>, 16101-16110. PMCID: PMC3187658<\/strong><\/a><\/p>\n

(100) Huang, H., Wang, H., Voehler, M. W., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S., Stone, M. P. (2011) \u03b3-Hydroxy-1,N<\/em>2-propano-2\u2019-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage<\/a>. Chem. Res.Toxicol., 24<\/em>, 1123-1133. PMCID: PMC3138414<\/a><\/strong><\/p>\n

(99) Shanmugam, G., Kozekov, I. D., Guengerich, F. P., Rizzo, C. J., Stone, M. P. (2011) 1,N<\/em>2-Etheno-2′-deoxyguanosine adopts the syn<\/em> conformation about the glycosyl bond when mismatched with deoxyadenosine<\/a>. Chem. Res. Toxicol., 24<\/em>, 1071-1079. PMCID: PMC3138413<\/strong><\/a><\/p>\n

(98) Polavarapu, P. L., Donahue, E. A., Shanmugam, G., Scalmani, G., Hawkins, E. K., Rizzo, C., Ibnusaud, I., Thomas, G., Habal, D., Sebastian, D. (2011) A single chiroptical spectroscopic method may not be able to establish the absolute configurations of diastereomers: Dimethylesters of hibiscus and garcinia acids<\/a>. J. Phys.<\/em> Chem. <\/em>A, 115<\/em>, 5665-5673. PMCID: PMC3702036<\/strong><\/a><\/p>\n

(97) Petrova, K. V., Stec, D, F., Voehler, M. W., Rizzo, C. J. (2011) Synthesis of the four stereoisomers of 2,3-epoxy-4-hydroxynonanal and their reactivity with deoxyguanosine<\/a>. Org. Biomol. Chem.<\/em>, 9<\/em>, 1960-1971. PMCID: PMC3694406<\/strong><\/a><\/p>\n

(96) Polavarapu, P. L., Scalmani, G., Hawkins, E. K., Rizzo, C., Jeirath, N., Ibnusaud, I., Habal, D., Nair, D. S., Haleema, S., (2011) Importance of solvation in understanding the chiroptical spectra of natural products in solution phase: Garcinia acid dimethyl ester<\/a>. J. Nat. Prod.<\/em> 74<\/em>, 321-328. PMCID: PMC3699186<\/strong><\/a><\/p>\n

2010<\/strong><\/p>\n

(95) Kozekov, I. D.,Turesky, R. J., Alas, G. R., Harris, C. M., Harris, T. M., Rizzo. C. J. (2010) Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal<\/a>. Chem. Res. Toxicol. 23<\/em>, 1701-1713. PMCID: PMC2990652<\/strong><\/a><\/p>\n

(94) Maddukuri, L., Eoff, R. L., Choi, J. Y., Rizzo, C. J., Guengerich, F. P., Marnett, L.J. (2010) In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases \u03ba, \u03b9, and Rev1<\/a>, Biochemistry<\/em> 49<\/em>, 8415-8424. PMCID: PMC2943251<\/a><\/strong><\/p>\n

(93) Christov, P. P., Banerjee, S., Stone, M. P., Rizzo, C. J. (2010) Selective incision of the \u03b1-N<\/em>5-methyl formamidopyrimidine anomer by Escherichia coli<\/em> Endonuclease IV<\/a>, J. Nucleic Acids<\/em>, 2010<\/strong>, Article ID 850234, doi:10.4061\/2010\/850234.\u00a0 PMCID: PMC2925382<\/strong><\/a><\/p>\n

(92) Huang, H., Kozekov, I. D., Kozekova, A. Rizzo, C. J., McCullough, A. K., Lloyd, R. S., Stone, M. P. (2010) Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N<\/em>2-\u03b3-hydroxy-propanodeoxyguanosine lesion with a trimethylene linkage<\/a>, Biochemistry<\/em> 49<\/em>, 6155\u20136164. PMCID: PMC2907095<\/a><\/strong><\/p>\n

(91) Huang, H., Kozekov, I. D., Kozekova, A. Wang, H., Lloyd, R. S., Rizzo, C. J., Stone, M. P. (2010) DNA cross-links induced by trans<\/em>-4-hydroxynonenal<\/a>. Environ. Mol. Mutagen.<\/em> 51<\/em>, 625-634. PMCID: PMC3140422<\/strong><\/a><\/p>\n

(90) Christov, P. P., Petrova, K. V., Shanmugam, G., Kozekov, Kozekova, A., Guengerich, F. P., Stone, M. P., Rizzo, C. J. (2010) Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N<\/em>2-etheno-2′-deoxyguanosine and 1,N<\/em>2-etheno-2′-deoxyguanosine lesions by Sulfolobus solfataricus<\/em> P2 DNA polymerase IV<\/a> (Dpo4). Chem. Res. Toxicol.<\/em> 23<\/em>, 1330-1341. PMCID: PMC2922457<\/a><\/strong><\/p>\n

(89) Christov, P. P., Chowdhury, G., Garmendia, C. A., Wang, F., Stover, J. S., Elmquist, C. E., Kozekova, A., Angel, K. C., Turesky, R. J., Stone, M. P., Guengerich, F. P., Rizzo, C. J. (2010) The C8-2′-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d<\/em>]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline (IQ), is a block to replication in vitro.<\/a> Chem. Res.Toxicol., 23<\/em>, 1076-1088. PMCID: PMC2891123<\/a><\/strong><\/p>\n

(88) Shanmugam, G., Kozekov, I. D., Guengerich, F. P., Rizzo, C. J., Stone, M. P. (2010) Structure of the 1,N<\/em>2-etheno-2′-deoxyguanosine lesion in the 3′-G(1,N<\/em>2-\u03b5dG)T-5′ sequence opposite a one-base deletion<\/a>. Biochemistry<\/em>, 2010<\/strong>, 49<\/em>, 2615-2626. PMCID: PMC2844103<\/a><\/strong><\/p>\n

(87) Liu, M., Bandaru, V., Bond, J. P., Jaruga, P., Zhao, X., Christov, P. P., Burrows, C. J., Rizzo, C. J., Dizdaroglu, M., Wallace, S. S. (2010) The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo<\/a>. Proc. Natl. Acad. Sci. U.S.A.<\/em> 107<\/em>, 4925-4930. PMCID: PMC2841873<\/a><\/strong><\/p>\n

(86) Yamanaka, K., Minko, I. G., Takata, K.-i., Kolbanovskiy, A., Kozekov, I. D., Wood, R. D., Rizzo, C. J., Lloyd, R. S. (2010) Novel enzymatic function of DNA polymerase \u03bd in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links<\/a>. Chem. Res. Toxicol.23<\/em>, 689-695. PMCID: PMC2838406<\/a><\/strong><\/p>\n

2009<\/strong><\/p>\n

(85) Wang, L. C., Ben-Yehoyada, M., Kozekov, I. D., Rizzo, C. J., Gottesman, M. E., Gautier, J. (2009) Checkpoint signaling from a single DNA interstrand crosslink<\/a>. Mol. Cell<\/em>, 2009, 35<\/em>, 704-715. PMCID: PMC2756577<\/a><\/strong><\/p>\n

(84) Zhang, H., Bren, U., Kozekov, I. D., Rizzo, C. J., Stec, D. F., Guengerich, F. P. (2009) Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases<\/a>. J. Mol. Biol.<\/em> 392<\/em>, 251-269. PMCID: PMC2755575<\/a><\/strong><\/p>\n

(83) Eoff, R. L., Stafford, J. B., Szekely, J., Rizzo, C. J., Egli, M., Guengerich, F. P., Marnett, L. J. (2009) Structural and functional analysis of Sulfolobus solfataricus<\/em> Y-Family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct<\/a>. Biochemistry<\/em> 48<\/em>, 7079-7088. PMCID: PMC2717710<\/a><\/strong><\/p>\n

(82) Zhang, H., Eoff, R. L., Kozekov, I. D., Rizzo, C. J., Egli, M., Guengerich, F. P. (2009) Structure-function relationships in miscoding by Sulfolobus solfataricus<\/em> DNA polymerase Dpo4: Guanine N<\/em>2,N<\/em>2-dimethyl substitution produces inactive and miscoding polymerase complexes<\/a>. J. Biol. Chem.<\/em> 284<\/em>, 17687-17699. PMCID: PMC2755575<\/a><\/strong><\/p>\n

(81) Huang, H., Kim, H.-Y., Kozekov, I. D., Cho, Y.-J., Wang, H., Kozekova, A., Harris, T. M., Rizzo, C. J., Stone, M. P. (2009) Stereospecific formation of the (R<\/em>)-\u03b3-hydroxytrimethylene interstrand N<\/em>2-dG:N<\/em>2-dG cross-link arising from the \u03b3-OH-1,N<\/em>2-propano-2\u2032-deoxyguanosine adduct in the 5\u2032-CpG-3\u2032 DNA sequence<\/a>. J. Am. Chem. Soc.<\/em> 131<\/em>, 8416-8424.PMCID: PMC2753404<\/a><\/strong><\/p>\n

(80) Christov, P. P., Angel, K. C., Guengerich, F. P., Rizzo, C. J. (2009) Replication past the N<\/em>5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry<\/a>. Chem. Res. Toxicol.22<\/em>, 1086-1095. PMCID: PMC2754150<\/a><\/strong><\/p>\n

(79) Minko, I. G., Kozekov, I. D., Harris, T. M., Rizzo, C. J., Lloyd, R. S., Stone, M. P. (2009) Chemistry and biology of DNA containing 1,N<\/em>2-deoxyguanosine adducts of the \u03b1,\u03b2-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal<\/a>. Chem. Res. Toxicol. 22<\/em>, 759-778. (cover article<\/a>) PMCID: PMC2685875<\/a><\/strong><\/p>\n

(78) Knutson, C. G., Rubinson, E. H., Akingbade, D., Anderson, C. S., Stec, D. F., Petrova, K. V., Kozekov, I. D., Guengerich, F. P., Rizzo, C. J., Marnett, L. J. (2009) Oxidation and glycolytic cleavage of etheno and propano DNA base adducts<\/a>. Biochemistry<\/em> 48<\/em>, 800-809. PMCID: PMC2975463<\/a><\/strong><\/p>\n

(77) Zhang, H., Eoff, R. L., Kozekov, I. D., Rizzo, C. J., Egli, M., Guengerich, F. P. (2009) Versatility of Y-family Sulfolobus solfataricus<\/em> DNA polymerase Dpo4 in translesion synthesis past bulky N<\/em>2-alkyl guanine adducts<\/a>. J. Biol. Chem. 284<\/em>, 3563-3576. (cover article<\/a>) PMCID: PMC2636699<\/a><\/strong><\/p>\n

(76) Stafford, J. B., Eoff, R. L., Kozekova, A., Rizzo, C. J., Guengerich, F. P., Marnett, L. J. (2009) Translesion DNA synthesis by human DNA polymerase \u03b7 on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2′-deoxy-\u03b2-D-erythro<\/em>-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H<\/em>)-one<\/a>. Biochemistry<\/em> 48<\/em>, 471-480. PMCID: PMC2651650<\/a><\/strong><\/p>\n

(75) Huang, H., Wang, H., Lloyd, R. S., Rizzo, C. J., Stone, M. P. (2009) Conformational interconversion of the trans<\/em>-4-hydroxynonenal-derived (6S<\/em>,8R<\/em>,11S<\/em>) 1,N<\/em>2-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA.<\/a> Chem. Res. Toxicol.22<\/em>, 187-200. PMCID: PMC2645987<\/a><\/strong><\/p>\n

2008<\/strong><\/p>\n

(74) Christov, P. P., Brown, K. L., Kozekov, I. D., Stone, M. P., Harris, T. M., Rizzo, C. J. (2008) Site-specific synthesis and characterization of oligonucleotides containing an N<\/em>6-(2-deoxy-D-erythro<\/em>-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine lesion, the ring-opened product from N7-methylation of deoxyguanosine<\/a>. Chem. Res. Toxicol.21<\/em>, 2324-2333. PMCID: PMC2701371<\/a><\/strong><\/p>\n

(73) Huang, H., Wang, H., Qi, N., Lloyd, R. S., Rizzo, C. J., Stone, M. P. (2008) The stereochemistry of trans<\/em>-4-hydroxynonenal-derived exocyclic 1,N<\/em>2-2′-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5′-CpG-3′ sequence<\/a>. Biochemistry<\/em> 47<\/em>, 11457-11472. PMCID: PMC2646759<\/a><\/strong><\/p>\n

(72) Minko, I. D., Yamanaka, K., Kozekov, I. D., Kozekova, A., Indiani, C., O’Donnell, M. E., Jiang, Q., Goodman, M. F., Rizzo, C. J., Lloyd, R. S. (2008) Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family<\/a>. Chem. Res. Toxicol.21<\/em>, 1983-1990. PMCID: PMC2673917<\/a><\/strong><\/p>\n

(71) Shanmugam, G., Kozekov, I. D., Guengerich, F. P., Rizzo, C. J., Stone, M. P. (2008) Structure of the 1,N<\/em>2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2<\/a>. Chem. Res. Toxicol.21<\/em>, 1795-1805. PMCID: PMC2646752<\/a><\/strong><\/p>\n

(70) Christov, P. P., Kozekov, I. D., Rizzo, C. J., Harris, T. M. (2008) The formamidopyrimidine derivative of 7-(2-oxoethyl)-2′-deoxyguanosine<\/a>. Chem. Res. Toxicol.21<\/em>, 1777-1786. PMCID: PMC3138534<\/a><\/strong><\/p>\n

(69) Huang, H., Wang, H., Qi, N., Kozekova, A., Rizzo, C. J., Stone, M. P. (2008) Rearrangement of the (6S<\/em>,8R<\/em>,11S<\/em>) and (6R<\/em>,8S<\/em>,11R<\/em>) exocyclic 1,N<\/em>2-deoxyguanosine adducts of trans<\/em>-4-hydroxynonenal to N<\/em>2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA<\/a>. J. Am. Chem. Soc.<\/em> 130<\/em>, 10898-10906. PMCID: PMC2646763<\/a><\/strong><\/p>\n

(68) Dexheimer, T. S., Kozekova, A., Rizzo, C. J., Stone, M. P., Pommier, Y. (2008) The modulation of topoisomerase-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts<\/a>. Nucleic Acids Res.<\/em> 36<\/em>, 4128-4136. PMCID: PMC2475617<\/a><\/strong><\/p>\n

(67) Stone, M. P., Cho, Y.-J., Huang, H., Kim, H.-Y., Kozekov, I. D., Kozekova, A., Wang, H., Minko, I. G., Lloyd, R. S., Harris, T. M., Rizzo, C. J. (2008) Interstrand DNA cross-links induced by \u03b1,\u03b2-unsaturated aldehydes derived from lipid peroxidation and environmental sources<\/a>. Acc. Chem. Res.<\/em> 41<\/em>, 793-804. PMCID: PMC2785109<\/a><\/strong><\/p>\n

(66) Minko, I. G., Harbut, M. B., Kozekov, I. D., Kozekova, A., Jakobs, P. M., Olson, S. B., Moses, R. E., Harris, T. M., Rizzo, C. J., Lloyd, R. S. (2008) Role for DNA polymerase \u03ba in the processing of N<\/em>2-N<\/em>2-guanine interstrand cross-links.<\/a> J. Biol. Chem.<\/em> 283<\/em>, 17075-17082. PMCID: PMC2427349<\/a><\/strong><\/p>\n

(65) Szekely, J., Rizzo, C. J., Marnett, L. J. (2008) Chemical properties of oxopropenyl adducts of purine and pyrimidine nucleosides and their reactivity toward amino acid cross-link formation<\/a>. J. Am. Chem. Soc.<\/em> 130<\/em>, 2195-2201. PMCID: PMC2708936<\/a><\/strong><\/p>\n

(64) Szekely, J., Wang, H., Peplowski, K. M., Knutson, C. G., Marnett, L. J., Rizzo, C. J. (2008) “One-pot” syntheses of malondialdehyde adducts of nucleosides<\/a>. Nucleosides Nucleotides & Nucleic Acids<\/em> 27<\/em>, 103-109. PMCID: PMC3129002<\/a><\/strong><\/p>\n

(63) Minko, I. G., Kozekov, I. D., Kozekova, A., Harris, T. M., Rizzo, C. J., Lloyd, R. S. (2008) Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts<\/a>. Mutat. Res.<\/em> 637<\/em>, 161-172. PMCID: PMC3181171<\/a><\/strong><\/p>\n

2007<\/strong><\/p>\n

(62) Stover, J. S., Rizzo, C. J. (2007) Synthesis of oligonucleotides containing the N<\/em>2-deoxyguanosine adduct of the dietary carcinogen 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline<\/a>. Chem. Res. Toxicol.20<\/em>, 1972-1979. PMCID: PMC3138521<\/a><\/strong><\/p>\n

(61) Knutson, C. G., Wang, H. Rizzo C. J., Marnett, L. J. (2007) Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-\u03b2-D-erythro<\/em>-pentofuranosyl)-pyrimido[1,2-a]purine-10(3H<\/em>)-one, in the rat<\/a>. J. Biol. Chem.<\/em> 282<\/em>, 36257-36264. PMID: 17951255<\/a><\/strong><\/p>\n

(60) Petrova, K. V., Jalluri, R. S., Kozekov I. D., Rizzo, C. J.. (2007) Mechanism of 1,N<\/em>2-etheno-2′-deoxyguanosine formation from epoxyaldehydes<\/a>. Chem. Res. Toxicol.20<\/em>, 1685-1692. PMCID: PMC3133930<\/a><\/strong><\/p>\n

(59) Shanmugam, G., Goodenough, A. K. Kozekov, I. D., Guengerich, F. P., Rizzo C. J., Stone, M. P.. (2007) Structure of the 1,N<\/em>2-etheno-2′-deoxyguanosine adduct in duplex DNA at pH 8.6<\/a>. Chem. Res. Toxicol. 20<\/em>, 1601-1611. PMCID: PMC2546360<\/a><\/strong><\/p>\n

(58) Wang, F., Elmquist, C. E., Stover, J. S., Rizzo, C. J., Stone, M. P. (2007) DNA sequence modulates the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline in the recognition sequence of the Nar<\/em>I restriction enzyme.<\/a> Biochemistry<\/em> 46<\/em>, 8498-8516. PMCID: PMC2782574<\/a><\/strong><\/p>\n

(57) Cho, Y.-J., Kozekov, I. D., Harris, T. M., Rizzo, C. J., Stone, M. P. (2007) Stereochemistry modulates the stability of reduced interstrand cross-links arising from R<\/em>– and S<\/em>-\u03b1-CH3-\u03b3-OH-1,N<\/em>2-propano-2′-deoxyguanosine in the 5′-CpG-3′ DNA sequence<\/a>. Biochemistry<\/em> 46<\/em>, 2608-2621. PMCID: PMC2581467<\/a><\/strong><\/p>\n

(56) Elmquist, C. E., Wang, F., Stover, J. S., Stone, M. P., Rizzo, C. J. (2007) Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline (IQ) within the Nar<\/em>I recognition sequence<\/a>. Chem. Res. Toxicol.20<\/em>, 445-454. PMCID: PMC2743555<\/a><\/strong><\/p>\n

(55) Stover, J. S., Ciobanu, M., Cliffel, D. E., Rizzo, C. J. (2007) Chemical and electrochemical oxidation of C8-arylamine adducts of 2′-deoxyguanosine<\/a>. J. Am. Chem. Soc.<\/em> 129<\/em>, 2074-2081. PMCID: PMC2526121<\/a><\/strong><\/p>\n

2006<\/strong><\/p>\n

(54) Stover, J. S., Chowdhury, G., Zang, H., Guengerich, F. P., Rizzo, C. J. (2006) Translesion synthesis past the C8- and N<\/em>2-deoxyguanosine adducts of the dietary mutagen 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline in the Nar<\/em>I recognition sequence by prokaryotic DNA polymerases<\/a>. Chem. Res. Toxicol.19<\/em>, 1506-1517. PMCID: PMC3150502<\/a><\/strong><\/p>\n

(53) Wang, H., Kozekov, I. D., Kozekova, A., Tamura, P. J., Marnett, L. J., Harris, T. M., Rizzo, C. J. (2006) Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy<\/a>. Chem. Res. Toxicol.19<\/em>, 1467-1474. PMCID: PMC2441645<\/a><\/strong><\/p>\n

(52) Choi, J.-Y., Stover, J. S., Angel, K. C., Chowdhury, G., Rizzo, C. J., Guengerich, F. P. (2006) Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase h selectively produces a two-base deletion in copying the N<\/em>2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline but not the C8 adduct at the Nar<\/em>I G3 site<\/a>. J. Biol. Chem.<\/em> 281<\/em>, 25297-25306. PMID: 16835218<\/a><\/strong><\/p>\n

(51) Cho, Y.-J., Wang, H., Kozekov, I. D., Kozekova, A., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Rizzo, C. J., Lloyd, R. S., Stone, M. P. (2006) Orientation of the crotonaldehyde-derived N<\/em>2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5′-CpG-3′ sequence<\/a>. Chem. Res. Toxicol.19<\/em>, 1019-1029. PMID: 16918240<\/a><\/strong><\/p>\n

(50) Wang, F., DeMuro, N. E., Elmquist, C. E., Stover, J. S., Rizzo, C. J., Stone, M. P. (2006) Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f<\/em>]quinoline in the recognition sequence of the Nar<\/em>I restriction enzyme, a hotspot for -2 bp deletions<\/a>. J. Am. Chem. Soc.<\/em> 128<\/em>, 10085-10095. PMCID: PMC2692337<\/a><\/strong><\/p>\n

(49) Choi, J.-Y., Zang, H., Angel, K. C., Kozekov, I. D., Goodenough, A. K., Rizzo, C. J., Guengerich, F. P. (2006) Translesion synthesis across 1,N<\/em>2-ethenoguanine by human DNA polymerases<\/a>. Chem. Res. Toxicol.19<\/em>, 879-886. PMCID: PMC3130186<\/a><\/strong><\/p>\n

(48) Otteneder, M., Knutson, C., Daniels, J., Hashim, M., Crews, B., Remmel, R., Wang, H., Rizzo, C., Marnett, L. (2006) In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG<\/a>. Proc. Natl. Acad. Sci. U.S.A.<\/em> 103<\/em>, 6665-6669. PMCID: PMC1458938<\/strong><\/a><\/p>\n

(47) Cho, Y.-J., Wang, H., Kozekov, I. D., Kurtz, A., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Lloyd, R. S., Rizzo, C. J., Stone, M. P. (2006) Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived \u03b1-CH3-\u03b3-OH-1,N<\/em>2-propano-2′-deoxyguanosine adducts in the 5′-CpG-3′ sequence<\/a>. Chem. Res. Toxicol.19<\/em>, 195-208. PMCID: PMC2631444<\/a><\/strong><\/p>\n

2005<\/strong><\/p>\n

(46) Goodenough, A. K., Kozekov, I. D., Zang, H., Choi, J.-Y., Guengerich, F. P., Harris, T. M., Rizzo, C. J. (2005) Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a<\/em>]purin-9-one base, an intermediate in the formation of 1,N<\/em>2-etheno-2′-deoxyguanosine<\/a>. Chem. Res. Toxicol.<\/em> 18<\/em>, 1701-1714. PMCID: PMC3135970<\/a><\/strong><\/p>\n

(45) Zang, H., Goodenough, A. K., Choi, J.-Y., Irimia, A., Loukachevitch, L. V., Kozekov, I. D., Angel, K. C., Rizzo, C. J., Egli, M., Guengerich, F. P. (2005) DNA adduct bypass polymerization by Sulfolobus solfataricus<\/em> DNA polymerase Dpo4: Analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N<\/em>2-ethenoguanine.<\/a> J. Biol. Chem.<\/em> 280<\/em>, 29750-29764. (cover article<\/a>) PMID: 15965231<\/a><\/strong><\/p>\n

(44) Cho, Y.-J., Kim, H., Huang, H., Slutsky, A., Minko, I. G., Wang, H., Nechev, L. V., Kozekov, I. D., Kozekova, A., Tamura, P., Jacob, J., Voehler, M., Harris, T. M., Lloyd, R. S., Rizzo, C. J., Stone, M. P. (2005) Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5′-CpG-3′ sequence by the acrolein-derived \u03b3-OH-1,N<\/em>2-propano-2′-deoxyguanosine DNA adduct<\/a>. J. Am. Chem. Soc.<\/em> 127<\/em>, 17686-17696. PMCID: PMC2631571<\/a><\/strong><\/p>\n

(43) Scholdberg, T. A., Merritt, W. K., Dean, S. M., Kowalcyzk, A., Harris, C. M., Harris, T. M., Rizzo, C. J., Lloyd, R. S., Stone, M. P. (2005) Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 \u03b2-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence<\/a>. Biochemistry<\/em> 44<\/em>, 3327-3337. PMID: 15736943<\/a><\/strong><\/p>\n

2004<\/strong><\/p>\n

(42) Stover, J. S., Rizzo, C. J. (2004) Synthesis of the N<\/em>2-deoxyguanosine adduct of the potent dietary mutagen IQ<\/a>. Org. Lett.<\/em> 6<\/em>, 4985-4988. PMID: <\/a><\/strong>15606116<\/strong><\/a><\/p>\n

(41) Elmquist, C. E., Stover, J. S., Wang, Z., Rizzo, C. J. (2004) Site-specific synthesis and properties of oligonucleotides containing C8-deoxyguanosine adducts of the dietary mutagen IQ<\/a>. J. Am. Chem. Soc.<\/em> 126<\/em>, 11189-11201. PMID: 15355100<\/a><\/strong><\/p>\n

(40) Brock, A. K., Kozekov, I. D., Rizzo, C. J., Harris, T. M. (2004) Coupling products of nucleosides with the glyoxal adduct of deoxyguanosine<\/a>. Chem. Res. Toxicol.17<\/em>, 1047-1056. PMID: <\/a><\/strong>15310236<\/strong><\/a><\/p>\n

(39) West, J. D., Ji, C., Duncan, S. T., Amarnath, V., Schneider, C., Rizzo, C. J., Brash, A. R., Marnett, L. J. (2004) Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation<\/a>. Chem. Res. Toxicol.<\/em> 17<\/em>, 453-462. PMID: 16351098<\/a><\/strong><\/p>\n

(38) Wang, H., Marnett, L. J., Harris, T. M., Rizzo, C. J. (2004) A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine<\/a>. Chem. Res. Toxicol.<\/em> 17<\/em>, 144-149. (cover article<\/a>) PMID: 14967001<\/a><\/strong><\/p>\n

2003<\/strong><\/p>\n

(37) Rezaei, M., Harris, T. M., Rizzo, C. J. (2003) Stereoselective synthesis of the 1,N<\/em>2-deoxyguanosine adducts of cinnamaldehyde.\u00a0 A stereocontrolled route to deoxyguanosine adducts of \u03b1,\u03b2-unsaturated aldehydes<\/a>. Tetrahedron Lett<\/em> 44<\/em>, 7513-7516.<\/p>\n

(36) Fernandes, P. H., Wang, H., Rizzo, C. J., Lloyd, R. S. (2003) Site-specific mutagenicity of stereochemically defined 1,N<\/em>2-deoxyguanosine adducts of trans<\/em>-4-hydroxynonenal in mammalian cells<\/a>. Environ. Mol. Mutagen.<\/em> 42<\/em>, 68-74. PMID: 12929118<\/a><\/strong><\/p>\n

(35) Wang, H., Kozekov, I. D., Harris, T. M., Rizzo, C. J. (2003) Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N<\/em>2-deoxyguanosine adducts of the lipid peroxidation product trans<\/em>-4-hydroxynonenal<\/a>. J. Am. Chem. Soc.<\/em> 125<\/em>, 5687-5700. PMID: 12733907<\/strong><\/a><\/p>\n

(34) Kozekov, I. D., Nechev, L. V., Moseley, M. S., Harris, C. M., Rizzo, C. J., Stone, M. P., Harris, T. M. (2003) DNA interchain cross-links formed by acrolein and crotonaldehyde<\/a>. J. Am. Chem. Soc.<\/em> 125<\/em>, 50-61. PMID: 12515506<\/a><\/strong><\/p>\n

2002<\/strong><\/p>\n

(33) Nechev, L. V., Kozekov, I. D., Brock, A. K., Rizzo, C. J., Harris, T. M. (2002) DNA adducts of acrolein: Site-specific synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a<\/em>]purin-10(3H<\/em>)-one, an acrolein adduct of guanine.<\/a> Chem. Res. Toxicol.15<\/em>, 607-613. PMID: 12018980<\/a><\/strong><\/p>\n

(32) Guo, F., Chang, B. H., Rizzo, C. J. (2002) An N1-hydrogen bonding model for flavin coenzyme<\/a>. Bioorg. Med. Chem. Lett.<\/em> 12<\/em>, 151-154. PMID: 1175534<\/a><\/strong><\/p>\n

2001<\/strong><\/p>\n

(31) Wang, H., Rizzo, C. J. (2001) Stereocontrolled syntheses of all four stereoisomeric 1,N<\/em>2-deoxyguanosine adducts of the lipid peroxidation product trans<\/em>-4-hydroxynonenal<\/a>. Org. Lett.<\/em> 3<\/em>, 3603-3605. PMID: <\/a><\/strong>11678719<\/strong><\/a><\/p>\n

(30) Rizzo, C. J. (2001) Further computational studies on the conformation of 1,5-dihydrolumiflavin<\/a>. Antioxid. Redox Signal. 3<\/em>, 737-746. PMID: 11761324<\/a><\/strong><\/p>\n

(29) Wang, F., Wang, H., Polavarapu, P.L., Rizzo C. J. (2001) Absolute configuration and conformational stability of (+)-2,5-dimethylthiolane and (-)-2,5-dimethylsulfolane<\/a>. J Org Chem.<\/em> 66<\/em>, 3507-3512. PMID: 11348137<\/a><\/strong><\/p>\n

(28) Wang, Z. and Rizzo, C. J. (2001) Synthesis of the C8-deoxyguanosine adduct of the food mutagen IQ.<\/a> Org. Lett.<\/em> 3<\/em>, 565-568. PMID: 11178826<\/a><\/strong><\/p>\n

(27) Drabowicz, J., Dudzi\u0144ski, B., Miko\u0142ajczyk, M., Wang, F., Dehlavi, A., Goring, J., Park, M., Rizzo, C. J., Polavarapu, P. L., Biscarini, P., Wieczorek, M. W., Majzner W. R. (2001) Absolute configuration, predominant conformation and vibrational circular dichroism spectra of enantiomers of n<\/em>-butyl t<\/em>-butyl sulfoxide<\/a>. J. Org. Chem.<\/em> 66<\/em>, 1122-1129. PMID: 11312938<\/a><\/strong><\/p>\n

2000<\/strong><\/p>\n

(26) Wang, Z., Prudhomme, D. R., Buck, J. R., Park, M., Rizzo, C. J. (2000) Stereocontrolled synthesis of deoxynucleosides via photoinduced electron transfer deoxygenation of benzoyl protected arabino- and ribonucleosides.<\/a> J. Org. Chem.<\/em> 65<\/em>, 5969-5985. PMID: 10987930<\/a><\/strong><\/p>\n

(25) Reibenspies, J. H., Guo, F., Rizzo, C. J. (2000) X-ray crystal structures of conformationally biased flavin models<\/a>. Org. Lett.<\/em> 2<\/em>, 903-906. PMID: 10768182<\/a><\/strong><\/p>\n

(24) Wang, Z., Rizzo, C. J. (2000) Regioselective synthesis of \u03b2-N1 and \u03b2-N3 alloxazine nucleosides<\/a>. Org. Lett.<\/em> 2<\/em>, 227-230. PMID: 10814288<\/a><\/strong><\/p>\n

1999<\/strong><\/p>\n

(23) Prudhomme, D. R., Park,M., Wang, Z., Buck, J. R., Rizzo, C. J. (1999) Synthesis of deoxyribonucleosides: 3′,5′-Di-O<\/em>-benzoylthymidine<\/a>. Org. Synth.<\/em> 77<\/em>, 162-173.<\/p>\n

(22) Buck, J. R., Park, M., Wang, Z., Prudhomme, D. R., Rizzo, C. J. (1999) 3,6-Dimethyl-9-ethylcarbazole<\/a>. Org. Synth.77<\/em>, 153-161.<\/p>\n

1998<\/strong><\/p>\n

(21) Park, M., Buck, J. R., Rizzo, C. J. (1998) A convenient synthesis of 3,6-substituted carbazoles<\/a>. Tetrahedron,54<\/em>, 12707-12714.<\/p>\n

(20) Hasford, J. J., Rizzo, C. J. (1998) A linear free energy substituent effect on flavin redox chemistry<\/a>. J. Am. Chem.\u00a0Soc. 120<\/em>, 2251-2255.<\/p>\n

(19) Hasford, J. J., Rizzo, C. J. (1998) Reduction of Hg(II)\u2022EDTA with conformationally biased flavins<\/a>. Tetrahedron Lett.<\/em> 39<\/em>, 1317-1320.<\/p>\n

1997<\/strong><\/p>\n

(18) Wang, Z., Rizzo, C. J. (1997) Stereocontrolled synthesis of \u03b1-2′-deoxyribonucleosides<\/a>.Tetrahedron Lett.<\/em> 38<\/em>, 8177-8180.<\/p>\n

(17) Prudhomme, D. R., Wang, Z., Rizzo, C. J. (1997) An improved photosensitizer for the photoinduced electron-transfer deoxygenation of benzoate and m<\/em>-(trifluoromethyl)benzoates<\/a>. J. Org. Chem. 62<\/em>, 8257-8260. PMID: 11671949<\/a><\/strong><\/p>\n

(16) Hasford, J. J., Kemnitzer, W., Rizzo, C. J. (1997) Conformational effects on flavin redox chemistry<\/a>. J. Org. Chem.<\/em> 62<\/em>, 5244-5245.<\/p>\n

1996<\/strong><\/p>\n

(15) Park, M., Rizzo, C. J. (1996) Stereocontrolled, de novo<\/em> synthesis of \u03b2-2′-deoxyribonucleosides<\/a>. J. Org. Chem.<\/em> 61<\/em>, 6092-6093. PMID: 11667437<\/strong><\/a><\/p>\n

(14) Brown, S. A., Rizzo, C. J. (1996) A \u2018one-pot\u2019 alkylation\/hydrolysis of o<\/em>-nitrotrifluoroacetanilides.\u00a0 A convenient route to n<\/em>-alkyl o<\/em>-phenylenediamines<\/a>. Synth. Commun. 26<\/em>, 4065-4080.<\/p>\n

1995<\/strong><\/p>\n

(13) Parker, M. S. A., Rizzo, C. J.(1995) Facile addition of dichloroketene to acetylenes mediated by zinc and ultrasound<\/a>. Synth. Commun. 25<\/em>, 2781-9.<\/p>\n

1992<\/strong><\/p>\n

(12) Rizzo, C. J. (1992) Salt effects in a hydrophobically accelerated Diels-Alder reaction follows the Hofmeister series<\/a>. J. Org. Chem. <\/em>1992<\/strong>, 57<\/em>, 6382-4.<\/p>\n

From Graduate and Post-doctoral Work<\/strong><\/p>\n

(11) Smith, A. B., Wood, J. L., Wong, W., Gould, A. E., Rizzo. C. J., Barbosa, J., Funayama, S., Komiyama, K., Omura, S., (1996) (+)-Trienomycins A, B, C and F and (+)-mycotrienins I and II: Relative and absolute stereochemistry.<\/a> J. Am. Chem.\u00a0Soc.<\/em> 118<\/em>, 8308-8315.<\/p>\n

(10) Smith, A. B., Wood, J. L., Rizzo, C. J., Furst , G. T., Carroll, P. J., Donohue, J., Omura, S. (1992) (+)-Hitachimycin:\u00a0 Stereochemistry and conformational analysis.<\/a> J. Am. Chem.\u00a0Soc.114<\/em> , 8003-8007.<\/p>\n

(9) Dougherty, J. P., Rizzo C. J., Breslow, R. (1992) Oligodeoxynucleotides that contain 2′,5” linkages: Synthesis and hybridization properties.<\/a> J. Am. Chem.\u00a0Soc. 114<\/em>, 6254-6255<\/p>\n

(8) Rizzo, C. J., Dougherty J. P., Breslow, R. (1992) 3′-Deoxy-2′-phosphoramidites of adenosine and 5-methyluridine used for the solid phase synthesis of unnatural 3′-deoxy-2′,5”-oligonucleotides<\/a>. Tetrahedron Lett.<\/em>, 33<\/em>, 4129-4133.<\/span><\/p>\n

(7) Breslow, R., Rizzo, C. J. (1991) Chaotropic salt effects in a hydrophobically accelerated Diels-Alder reaction<\/a>. J. Am. Chem.\u00a0Soc. 113<\/em>, 4340-4341.<\/span><\/p>\n

(6) Rizzo, C. J., and Smith, A. B. (1991) Aphidicolin synthetic studies:\u00a0 A stereocontrolled end game<\/a>. J. Chem. Soc., Perkin Trans. I,<\/em> 1991<\/strong>, 969-979.
\n<\/span><\/p>\n

(5) Rizzo, C. J., Wood, J. L., Furst , G. T., Smith, A. B. (1990) Aphidicolin synthetic studies, 2. 2D-NMR analysis of (+)-aphidicolin and its degradation products 3a,18-dihydroxy-17-noraphidicolan-16-one and 3a,18-isopropylidenedioxy-17-noraphidicolan-16-one. Complete 1H and 13C assignments.<\/a> J. Nat. Prod. <\/em>1990<\/strong>, 53<\/em>, 735-739.
\n<\/span><\/p>\n

(4). Smith, A. B., Wood, J. L., Wong, W., Gould, A. E., Rizzo. C. J., Funayama, S. Omura, S. (1990) (+)-Trienomycins A, B, and C: Relative and absolute stereochemistry<\/a>. J. Am. Chem.\u00a0Soc.,<\/em> 1990<\/strong>, 112<\/em>, 7425-7426.
\n<\/span><\/p>\n

(3) Smith, A. B., Wood, J. L., Rizzo. C. J., Furst , G. T., Carroll, P. J., Donohue, J., Omura, S. (1990) Solution and crystal structures of (+)-hitachimycin (stubomycin).<\/a> J. Org. Chem. 55<\/em>, 1133-1135.<\/span><\/p>\n

(2) Rizzo, C. J., Smith, A. B.<\/span> (1990) A new end game for aphidicolin<\/a>. Tetrahedron Lett.29<\/em>, 2793-2796<\/p>\n

(1) Rizzo, C. J., Dunlap, N. K., Smith, A. B.<\/span> (1987) A convenient preparation of 4- and 5-substituted cyclopentenones: A short synthesis of methylenomycin B<\/a>. J. Org. Chem.52<\/em>, 5280-5283.<\/p>\n

 <\/p>\n

Non Peer-Reviewed<\/strong><\/p>\n

(3) Stone, M. P., Huang, H., Cho, Y.-J., Kim,H.-Y., Kozekov, I. D., Kozekova, A., Wang ,H.,. Minko, I. G., Lloyd, R. S., Harris, T. M., Rizzo, C. J. (2010) Interstrand DNA cross-linking of 1,N<\/em>2-deoxyguanosine adducts derived from \u03b1,\u03b2-unsaturated aldehydes: Structure-function relationships, in The Chemical Biology of DNA Damage<\/a><\/em>, Geacintov, N. E., & Broyde, S., Eds., Wiley-VCH, Weinheim, Germany, 2010<\/strong>, pp 203-216<\/p>\n

(2) Stover, J. S., Elmquist, C. E., Wang, F., Zang, H., Stone, M. P., Guengerich, F. P., Rizzo C. J., (2006) Synthesis, conformation, and bypass of carcinogen-modified oligonucleotides<\/a>. American Association for Cancer Research Education Book<\/em>, 2006<\/strong>, 207-210.
\n<\/span><\/p>\n

(1) Rizzo, C. J. (2005) N-Methylcarbazole<\/a>. Electronic Encyclopedia of Reagents for Organic Synthesis<\/em>, John Wily & Sons.<\/p>\n","protected":false},"excerpt":{"rendered":"

ORCID: 0000-0001-9005-611X\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 SCOPUS ID:\u00a07102642628 2019 (129) Chen, H., Yao, L., Rizzo, C. J., Turesky, R. J.\u00a0Quantitation of Apurinic\/Apyrimidinic Sites in Isolated DNA and in Mammalian Tissue with Reduced Artifact, \u00a0Anal. Chem., 2019, 91, (accepted).\u00a0PMID: 31055913 2018 (128) Bamberger, S.N., Malik, C.K., Voehler, M.W., Brown, S.K. Pan, K., Johnson Salyard,…<\/p>\n","protected":false},"author":272,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page_onecolumn.php","meta":[],"tags":[],"_links":{"self":[{"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/pages\/28"}],"collection":[{"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/users\/272"}],"replies":[{"embeddable":true,"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":27,"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/pages\/28\/revisions"}],"predecessor-version":[{"id":1210,"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/pages\/28\/revisions\/1210"}],"wp:attachment":[{"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/media?parent=28"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp0.vanderbilt.edu\/rizzolab\/wp-json\/wp\/v2\/tags?post=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}