Advanced Neuropathology and Molecular Mechanisms of Alzheimer’s Disease and Cerebral Amyloid Angiopathy

Matthew Schrag, M.D., Ph.D.
Assistant Professor at Vanderbilt University Medical Center
Department of Neurology
615-936-0060 (office)
matthew.schrag@vumc.org

Advanced neuropathology and molecular mechanisms of Alzheimer’s disease and cerebral amyloid angiopathy

The bulk of our work in the SchragLab is basic science related to identifying shared molecular mechanisms between cerebral amyloid angiopathy and Alzheimer’s disease. We study post-mortem human tissue with advanced microscopy techniques including CLARITY to understand changes in the vascular network associated cerebrovascular degeneration and neurodegeneration. We also work with basic cell biology and enzymology techniques to understand the function of novel Alzheimer’s disease risk genes. We have access to large human and animal datasets to assess functional phenotypes of genes of interest and conduct behavioral analysis in mouse models of Alzheimer’s disease and cerebral amyloid angiopathy. For students with clinical interests, we also have a small portfolio of clinical research projects related to cerebral amyloid angiopathy, intracerebral hemorrhage and stroke.

For more information, please visit the lab website.