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Donahue, Manus, Department of Radiology and Radiological Sciences

Manus Donahue, Ph.D.
Assistant Professor
Vanderbilt University Institute of Imaging Science
Room AAA-3115
615-322-8350 (office)

Manus J. Donahue, PhD, graduated from Duke University (BS: Physics; BA: Philosophy) and earned a PhD in Biophysics from The Johns Hopkins University School of Medicine. After completing a post-doctoral fellowship in Clinical Neurology at The University of Oxford, he joined the Johns Hopkins faculty in 2009 and in 2010 he moved to Vanderbilt University Medical Center. At Vanderbilt, he currently has appointments in the departments of Neurology, Psychiatry and Behavioral Sciences, Radiology and Radiological Sciences, and Physics and Astronomy and is a member of the Vanderbilt Brain Institute and Vanderbilt-Ingram Cancer Center.

His work is focused on using new imaging and computational approaches to characterize tissue function in health and disease. These approaches are sensitive to physiological parameters such as cerebral blood flow, cerebral blood volume, pH, oxygen extraction fraction and the cerebral metabolic rate of oxygen, parameters that may adjust prior to symptom expression and irreversible tissue damage in many diseases. Over the past six years, he has been the Principal Investigator of four NIH-funded clinical trials in which these approaches are applied in patients with atherosclerotic cerebrovascular disease, moyamoya disease and syndrome, and lymphatic disorders.

He also directs The Center for Vascular and Physiological Imaging (CVPI), a facility located on the ground floor of the Vanderbilt University Institute of Imaging Science (VUIIS). The CVPI is a resource for investigators seeking to perform controlled measurements of vascular reactivity and quantitative physiology by using advanced functional magnetic resonance imaging (fMRI) methods in conjunction with innovative vascular and neuronal stimuli.

He is a member of the FDA-established Brain panel to determine endpoints in clinical trials of patients with sickle cell disease, ad hoc member of several NIH study sections, CEO of biosight, LLC, which provides healthcare and clinical trials consulting services, and youth soccer coach in the Harpeth Valley YMCA.

For more information, please visit the lab website.