Theory, simulation, and modeling of cell signaling processes
The goal of my work is the development and application of numerical methods to understand signal transduction cascades in cells and their dysregulation in cancer.
My group efforts comprise a tri-partite approach to study cancer biology: (1) Development of modelling and simulation tools necessary to study signalling events across multiple spatiotemporal time-scales. To this end we use techniques of statistical mechanics, molecular simulation, mesoscale modelling, reaction kinetics, and cell-population modelling to develop a systems-level description of cellular environments. (2) Use developed tools to study signalling processes relevant to cancer phenotypes. (3) Collaborate with experimental and theoretical groups to test and expand our hypotheses to develop a fundamental understanding of the rules that govern functional genomics and systems biology.