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Center for Structural Biology

Available Hardware

Diffraction Equipment

The facility possesses three detectors in two separate locations.

In room 862 RRB :

  • Oxford Diffraction XcaliburPX Ultra with an ONYX CCD detector. The unit is served by an Oxford Cryojet cryostat. This detector is listed as “ONYX” on the instrument scheduling page.In room 5263 BIOSCI/MRB III :
  • Bruker Microstar microfocus rotating-anode X-ray generator with two Bruker Proteum PT135 CCD area detectors, X8Land X8R on kappa goniometers. Cryostats are Bruker Kryo-Flex.

Crystallization Equipment

The facility includes a room for viewing and recording crystallization experiments in room 5263 BIOSCI/MRB III

  • crystallization incubators maintained at a variety of temperatures
  • two Leica MZ12 microscopes with polarizer/analyzer; one with a CCD camera for photographing crystals.
  • Leica MZ6 microscope with polarizer/analyzer.

 

Pac-Van Robotic Crystallization Facility

Located in the Iverson Laboratory on the 4th floor of the Preston Research Building, the Pac-Van facility is fully equipped for high-throughput crystallization experiments including remote access to images from the automated imager. The imager is equipped with UV lighting to allow for fluorescence of proteins to identify protein crystals in crystallization drops.

  • Xantus LCP Robot: An automated liquid handling platform (Zinsser) is a modular robotic pipetting platform designed for preparation of lipidic cubic phase (LCP) crystallization trials for high-throughput membrane protein structure determination.
  • Mosquito Robot: Crystallization trial experiments can be performed quickly and efficiently in 96 well plates, using the Mosquito, a nanoliter dispensing high-throughput robot.
  • Hamilton Robot: The Hamilton MICROLAB STARlet robot performs liquid handling tasks and is based on superior air displacement pipetting technology. This increases accuracy and repeatability while providing chain of custody with pipette condition monitoring and recording. The robot has eight arms that work simultaneously, and the software is completely customizable to our needs.
  • Rock Imager: This is a robust, easy-to-use, automated imaging system for protein crystallization.